Concepedia

Microcluster Organization

Microcluster Organization is a structural and functional framework in immunology that refers to the spatially segregated, dynamic assembly of receptor-ligand complexes and signaling molecules into discrete micrometer-scale domains at the interface of immune cell interactions, distinguishing it from diffuse or uniform patterns of molecular distribution in the immune synapse.

56

Publications

6K

Citations

281

Authors

129

Institutions

Publications per year

2017–2026

15

Parents

Publications

56

Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2

Tadashi Yokosuka, Masako Takamatsu, Wakana Kobayashi-Imanishi et al. · The Journal of Experimental Medicine · 2012 · 1.2K citations · Full text

, , +17

T Cell Receptor-Proximal Signals Are Sustained in Peripheral Microclusters and Terminated in the Central Supramolecular Activation Cluster

Rajat Varma, Gabriele Campi, Tadashi Yokosuka et al. · Immunity · 2006 · 878 citations · Full text

, , +16

Actin and agonist MHC–peptide complex–dependent T cell receptor microclusters as scaffolds for signaling

Gabriele Campi, Rajat Varma, Michael L. Dustin · The Journal of Experimental Medicine · 2005 · 627 citations · Full text

, , +17

Visualizing dynamic microvillar search and stabilization during ligand detection by T cells

En Cai, Peter Beemiller, Casey Beppler et al. · Science · 2017 · 288 citations · Full text

, , +17

Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination

Sophie V. Pageon, Thibault Tabarin, Yui Yamamoto et al. · Proceedings of the National Academy of Sciences · 2016 · 243 citations · Full text

, , +17

1–5 of 56

Authors

281

  1. ML
    Michael L. Dustin

    New York University, United States

    6 publications · 2K citations

    6

    h-index

  2. TY
    Tadashi Yokosuka

    RIKEN Center for Integrative Medical Sciences, Japan

    6 publications · 2.2K citations

    6

    h-index

  3. TS
    Takashi Saito

    Chiba University, Japan

    5 publications · 2.2K citations

    5

    h-index

  4. AH
    Akiko Hashimoto

    RIKEN Center for Integrative Medical Sciences, Japan

    4 publications · 1.3K citations

    4

    h-index

  5. MA
    Miyuki Azuma

    Tokyo Medical and Dental University, Japan

    3 publications · 1.2K citations

    3

    h-index

1–5 of 281

Institutions

129

  1. National Institutes of Health

    Bethesda, United States

    7 h-index

    27 publications

    1.8K citations

  2. RIKEN Center for Integrative Medical Sciences

    Yokohama, Japan

    6 h-index

    24 publications

    8.8K citations

  3. New York University

    New York, United States

    5 h-index

    9 publications

    3.3K citations

  4. University of California, San Francisco

    San Francisco, United States

    3 h-index

    10 publications

    2.1K citations

  5. The University of Osaka

    Osaka, Japan

    3 h-index

    4 publications

    1.3K citations

  6. University of Oxford

    Oxford, United Kingdom

    3 h-index

    7 publications

    736 citations

  7. Howard Hughes Medical Institute

    Chevy Chase, United States

    3 h-index

    12 publications

    1.9K citations

  8. University of California, Berkeley

    Berkeley, United States

    3 h-index

    10 publications

    1.2K citations

1–8 of 129

Venues

  1. The Journal of Experimental Medicine

    5 publications · 2.2K citations

    5

    h-index

  2. The Journal of Immunology

    JI · 4 publications · 136 citations

    4

    h-index

  3. The Journal of Cell Biology

    JCB · 4 publications · 186 citations

    4

    h-index

  4. Nature Communications

    2 publications · 144 citations

    2

    h-index

  5. Immunity

    2 publications · 975 citations

    2

    h-index

1–5