Concepedia

Methylation Heterogeneity

Methylation Heterogeneity is a biological phenomenon characterized by the variation in DNA methylation patterns across individual cells or genomic regions within a tissue or population, distinguishing it from uniform or conserved methylation profiles.

141

Publications

13.4K

Citations

1.3K

Authors

507

Institutions

Publications per year

2017–2026

67

Parents

Publications

141

Accounting for cellular heterogeneity is critical in epigenome-wide association studies

Andrew E. Jaffe, Rafael A. Irizarry · Genome biology · 2014 · 1.2K citations · Full text

, , +14

Increased methylation variation in epigenetic domains across cancer types

Kasper D. Hansen, Winston Timp, Héctor Corrada Bravo et al. · Nature Genetics · 2011 · 1.1K citations · Full text

, , +16

Amount and distribution of 5-methylcytosine in human DNA from different types of tissues or cells

Melanie Ehrlich, Miguel A. Gama-Sosa, Lan-Hsiang Huang et al. · Nucleic Acids Research · 1982 · 1K citations · Full text

, , +14

Identification of methylation haplotype blocks aids in deconvolution of heterogeneous tissue samples and tumor tissue-of-origin mapping from plasma DNA

Shicheng Guo, Dinh Diep, Nongluk Plongthongkum et al. · Nature Genetics · 2017 · 581 citations

, , +11

The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space

Johanna Klughammer, Barbara Kiesel, Thomas Roetzer-Pejrimovsky et al. · Nature Medicine · 2018 · 330 citations

, , +17

1–5 of 141

Authors

1.3K

  1. RA
    Rafael A. Irizarry

    Johns Hopkins University, United States

    5 publications · 2.7K citations

    5

    h-index

  2. CB
    Christoph Bock

    CeMM Research Center for Molecular Medicine, Austria

    4 publications · 707 citations

    4

    h-index

  3. KD
    Kasper D. Hansen

    Johns Hopkins University, United States

    3 publications · 1.2K citations

    3

    h-index

  4. CP
    Christoph Plass

    Heidelberg University, Germany

    3 publications · 306 citations

    3

    h-index

  5. JK
    Johanna Klughammer

    CeMM Research Center for Molecular Medicine, Austria

    3 publications · 630 citations

    3

    h-index

1–5 of 1.3K

Institutions

507

  1. Johns Hopkins University

    Baltimore, United States

    12 h-index

    84 publications

    19.8K citations

  2. Heidelberg University

    Heidelberg, Germany

    9 h-index

    62 publications

    6.5K citations

  3. German Cancer Research Center

    Heidelberg, Germany

    8 h-index

    44 publications

    5.9K citations

  4. Inserm

    Paris, France

    7 h-index

    36 publications

    2.5K citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    7 h-index

    33 publications

    1.7K citations

  6. Johns Hopkins Medicine

    Baltimore, United States

    6 h-index

    33 publications

    13.3K citations

  7. University Hospital Heidelberg

    Heidelberg, Germany

    6 h-index

    10 publications

    877 citations

  8. University of California, Los Angeles

    Los Angeles, United States

    6 h-index

    46 publications

    4.9K citations

1–8 of 507

Venues

  1. Nucleic Acids Research

    9 publications · 1.5K citations

    9

    h-index

  2. Nature Communications

    8 publications · 960 citations

    8

    h-index

  3. Genome biology

    6 publications · 1.6K citations

    6

    h-index

  4. Epigenetics

    6 publications · 385 citations

    6

    h-index

  5. Scientific Reports

    4 publications · 230 citations

    4

    h-index

1–5