Concepedia

Metabolism-based Interactions

Metabolism-Based Interactions is a type of drug-drug interaction in which the metabolic pathway of one drug is altered by another, leading to changes in the rate or extent of its biotransformation and, consequently, in its pharmacokinetic profile and pharmacological effect.

40

Publications

2.5K

Citations

127

Authors

54

Institutions

Publications per year

2017–2026

4

Parents

Publications

40

Arene Oxides: A New Aspect of Drug Metabolism

D. M. JERINA, John W. Daly · Science · 1974 · 1K citations

, , +14

Metabolic Interactions Among Environmental Chemicals and Drugs

Allan H. Conney, J.J. Burns · Science · 1972 · 262 citations

, , +17

Fluorometric screening for metabolism-based drug–drug interactions

Charles L. Crespi, David M. Stresser · Journal of Pharmacological and Toxicological Methods · 2000 · 100 citations

, , +12

FDA Evaluations Using In Vitro Metabolism to Predict and Interpret In Vivo Metabolic Drug‐Drug Interactions: Impact on Labeling

Barbara M. Davit, Kellie S. Reynolds, Rae Yuan et al. · The Journal of Clinical Pharmacology · 1999 · 74 citations

, , +17

The rational selection of drug interaction studies: implications of recent advances in drug metabolism.

Tucker Gt · PubMed · 1992 · 72 citations

, , +17

1–5 of 40

Authors

127

  1. DM
    D. M. JERINA

    National Institutes of Health, United States

    1 publications · 1K citations

    1

    h-index

  2. BM
    Barbara M. Davit

    United States Food and Drug Administration, United States

    1 publications · 74 citations

    1

    h-index

  3. KD
    Kevin D. Croft

    The University of Western Australia, Australia

    1 publications · 20 citations

    1

    h-index

  4. TT
    Toshiyuki Takanohashi

    Ajinomoto (Japan), Japan

    1 publications · 26 citations

    1

    h-index

  5. EW
    Edward W. Moore

    Lemuel Shattuck Hospital, United States

    1 publications · 34 citations

    1

    h-index

1–5 of 127

Institutions

54

  1. Center for Drug Evaluation and Research

    Silver Spring, United States

    2 h-index

    18 publications

    1.1K citations

  2. Ajinomoto (Japan)

    Tokyo, Japan

    1 h-index

    3 publications

    78 citations

  3. The Alfred Hospital

    Melbourne, Australia

    1 h-index

    8 publications

    536 citations

  4. Duke Medical Center

    Durham, United States

    1 h-index

    2 publications

    20 citations

  5. University of Auckland

    Auckland, New Zealand

    1 h-index

    1 publications

    67 citations

  6. University of Tartu

    Tartu, Estonia

    1 h-index

    4 publications

    108 citations

  7. WSP (Canada)

    Montreal, Canada

    1 h-index

    1 publications

    100 citations

  8. University of Florida

    Gainesville, United States

    1 h-index

    1 publications

    56 citations

1–8 of 54

Venues

  1. PubMed

    Repository · 4 publications · 174 citations

    4

    h-index

  2. Science

    3 publications · 1.3K citations

    3

    h-index

  3. The Journal of Clinical Pharmacology

    2 publications · 119 citations

    2

    h-index

  4. Biochemical Pharmacology

    2 publications · 50 citations

    2

    h-index

  5. Clinical Pharmacokinetics

    2 publications · 28 citations

    2

    h-index

1–5