Concepedia

Metabolic Liabilities

Metabolic Liabilities is a pharmacological construct that denotes inherent structural or biochemical properties of a drug molecule which predispose it to undesirable metabolic transformations, thereby differentiating it from metabolically stable compounds by virtue of its potential to generate toxic or reactive metabolites.

28

Publications

2.4K

Citations

367

Authors

63

Institutions

Publications per year

2017–2026

15

Parents

Publications

28

Identification of the Clinical Development Candidate <b>MRTX849</b>, a Covalent KRAS<sup>G12C</sup> Inhibitor for the Treatment of Cancer

Jay B. Fell, John P. Fischer, Brian R. Baer et al. · Journal of Medicinal Chemistry · 2020 · 594 citations · Full text

, , +17

Spirotetrahydro β-Carbolines (Spiroindolones): A New Class of Potent and Orally Efficacious Compounds for the Treatment of Malaria

Bryan K. S. Yeung, Bin Zou, Matthias Rottmann et al. · Journal of Medicinal Chemistry · 2010 · 425 citations · Full text

, , +16

Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer

Volkan I. Sayin, Sarah E. LeBoeuf, Simranjit X. Singh et al. · eLife · 2017 · 231 citations · Full text

, , +17

MYC-Driven Small-Cell Lung Cancer is Metabolically Distinct and Vulnerable to Arginine Depletion

Milind D. Chalishazar, Sarah J. Wait, Fang Huang et al. · Clinical Cancer Research · 2019 · 182 citations

, , +17

Flux balance analysis predicts essential genes in clear cell renal cell carcinoma metabolism

Francesco Gatto, Heike Miess, Almut Schulze et al. · Scientific Reports · 2015 · 109 citations · Full text

, , +16

1–5 of 28

Authors

367

  1. MP
    María Prat

    Università degli Studi del Piemonte Orientale “Amedeo Avogadro”, Italy

    2 publications · 67 citations

    2

    h-index

  2. JC
    Julio C. Castro‐Palomino

    University of Konstanz, Germany

    2 publications · 67 citations

    2

    h-index

  3. JK
    Jaimie K. Rueter

    Neurocrine Biosciences (United States), United States

    2 publications · 67 citations

    2

    h-index

  4. SM
    Siobhan Malany

    Neurocrine Biosciences (United States), United States

    2 publications · 67 citations

    2

    h-index

  5. JP
    John P. Williams

    University of Toronto, Canada

    2 publications · 67 citations

    2

    h-index

1–5 of 367

Institutions

63

  1. Neurocrine Biosciences (United States)

    San Diego, United States

    2 h-index

    50 publications

    1.6K citations

  2. University of Minnesota

    Minneapolis, United States

    2 h-index

    11 publications

    427 citations

  3. Amgen (United States)

    Thousand Oaks, United States

    2 h-index

    42 publications

    1.7K citations

  4. Almirall (Spain)

    Barcelona, Spain

    2 h-index

    50 publications

    1.6K citations

  5. Abbott Fund

    Chicago, United States

    1 h-index

    2 publications

    24 citations

  6. Novartis Institutes for BioMedical Research

    Basel, Switzerland

    1 h-index

    24 publications

    10.2K citations

  7. Huazhong University of Science and Technology

    Wuhan, China

    1 h-index

    1 publications

    182 citations

  8. The University of Tokyo

    Tokyo, Japan

    1 h-index

    2 publications

    62 citations

1–8 of 63

Venues

  1. Journal of Medicinal Chemistry

    8 publications · 1.3K citations

    8

    h-index

  2. ACS Medicinal Chemistry Letters

    5 publications · 199 citations

    5

    h-index

  3. Frontiers in Physiology

    1 publications · 20 citations

    1

    h-index

  4. Expert Opinion on Therapeutic Patents

    1 publications · 12 citations

    1

    h-index

  5. Biopolymers

    1 publications · 13 citations

    1

    h-index

1–5