Concepedia

Metabolic Flux Optimization

Metabolic Flux Optimization is a computational or mathematical framework designed to identify optimal distributions of metabolic reaction rates within a biochemical network that maximize or minimize a specified physiological objective, such as growth rate or precursor production, under defined constraints.

81

Publications

4.7K

Citations

301

Authors

136

Institutions

Publications per year

2017–2026

19

Parents

Publications

81

Regulatory on/off minimization of metabolic flux changes after genetic perturbations

Tomer Shlomi, Omer Berkman, Eytan Ruppin · Proceedings of the National Academy of Sciences · 2005 · 466 citations

, , +15

OptForce: An Optimization Procedure for Identifying All Genetic Manipulations Leading to Targeted Overproductions

Sridhar Ranganathan, Patrick F. Suthers, Costas D. Maranas · PLoS Computational Biology · 2010 · 434 citations · Full text

, , +17

Simple constrained‐optimization view of acetate overflow in <i>E. coli</i>

Rita A. Majewski, Michael M. Domach · Biotechnology and Bioengineering · 1990 · 304 citations

, , +16

Network Context and Selection in the Evolution to Enzyme Specificity

Hojung Nam, Nathan E. Lewis, Joshua A. Lerman et al. · Science · 2012 · 298 citations · Full text

, , +17

Optimization‐based framework for inferring and testing hypothesized metabolic objective functions

Anthony P. Burgard, Costas D. Maranas · Biotechnology and Bioengineering · 2003 · 210 citations

, , +12

1–5 of 81

Authors

301

  1. SY
    Sang Yup Lee

    Korea Advanced Institute of Science and Technology, South Korea

    3 publications · 82 citations

    3

    h-index

  2. FJ
    Frank J. Bruggeman

    Vrije Universiteit Amsterdam, Netherlands

    3 publications · 271 citations

    3

    h-index

  3. BØ
    Bernhard Ø. Palsson

    University of California San Diego, United States

    3 publications · 437 citations

    3

    h-index

  4. BT
    Bas Teusink

    Vrije Universiteit Amsterdam, Netherlands

    3 publications · 257 citations

    3

    h-index

  5. JM
    Jeno M. Scharer

    University of Waterloo, Canada

    2 publications · 66 citations

    2

    h-index

1–5 of 301

Institutions

136

  1. Vrije Universiteit Amsterdam

    Amsterdam, The Netherlands

    4 h-index

    14 publications

    1.3K citations

  2. Chinese Academy of Sciences

    Beijing, China

    3 h-index

    14 publications

    970 citations

  3. Technische Universität Braunschweig

    Braunschweig, Germany

    2 h-index

    7 publications

    424 citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    2 h-index

    7 publications

    398 citations

  5. Carnegie Mellon University

    Pittsburgh, United States

    2 h-index

    6 publications

    744 citations

  6. Jiangnan University

    Wuxi, China

    2 h-index

    10 publications

    248 citations

  7. University of Illinois Urbana-Champaign

    Urbana, United States

    2 h-index

    7 publications

    322 citations

  8. KTH Royal Institute of Technology

    Stockholm, Sweden

    2 h-index

    7 publications

    131 citations

1–8 of 136

Venues

  1. Biotechnology and Bioengineering

    8 publications · 792 citations

    8

    h-index

  2. Computers & Chemical Engineering

    5 publications · 117 citations

    5

    h-index

  3. PLoS Computational Biology

    5 publications · 717 citations

    5

    h-index

  4. Journal of Theoretical Biology

    5 publications · 360 citations

    5

    h-index

  5. BMC Systems Biology

    4 publications · 173 citations

    4

    h-index

1–5