Concepedia

Messenger Rna Engineering

Messenger RNA Engineering is a nucleic acid engineering methodology that specifically involves the design, optimization, and functional modification of messenger RNA sequences to enable or enhance gene expression, stability, delivery, and translational efficiency in biotechnological and therapeutic applications.

30

Publications

3.9K

Citations

189

Authors

57

Institutions

Publications per year

2017–2026

17

Parents

Publications

30

Functional messenger RNAs are produced by SP6<i>in vitro</i>transcription of cloned cDNAs

Paul A. Krieg, Douglas A. Melton · Nucleic Acids Research · 1984 · 1.5K citations · Full text

, , +17

Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals

Stefanie Grund, Barbara L. Mui, Michael J. Hope et al. · Molecular Therapy · 2015 · 515 citations · Full text

, , +16

Programmable m6A modification of cellular RNAs with a Cas13-directed methyltransferase

Christopher Wilson, Peter J. Chen, Zhuang Miao et al. · Nature Biotechnology · 2020 · 328 citations · Full text

, , +16

An engineered T7 RNA polymerase that produces mRNA free of immunostimulatory byproducts

Athanasios Dousis, Kanchana Ravichandran, Elissa M. Hobert et al. · Nature Biotechnology · 2022 · 221 citations · Full text

, , +14

Theoretical basis for stabilizing messenger RNA through secondary structure design

Hannah K. Wayment-Steele, Do Soon Kim, Christian A. Choe et al. · Nucleic Acids Research · 2021 · 186 citations · Full text

, , +17

1–5 of 30

Authors

189

  1. EC
    Elena Chepurko

    Icahn School of Medicine at Mount Sinai, United States

    4 publications · 215 citations

    4

    h-index

  2. YH
    Yoav Hadas

    Icahn School of Medicine at Mount Sinai, United States

    4 publications · 215 citations

    4

    h-index

  3. LZ
    Lior Zangi

    Icahn School of Medicine at Mount Sinai, United States

    4 publications · 215 citations

    4

    h-index

  4. NS
    Nishat Sultana

    Icahn School of Medicine at Mount Sinai, United States

    4 publications · 215 citations

    4

    h-index

  5. MT
    Mohammad Tofael Kabir Sharkar

    Icahn School of Medicine at Mount Sinai, United States

    3 publications · 101 citations

    3

    h-index

1–5 of 189

Institutions

57

  1. Icahn School of Medicine at Mount Sinai

    New York, United States

    4 h-index

    34 publications

    2.1K citations

  2. Northwestern University

    Evanston, United States

    3 h-index

    7 publications

    303 citations

  3. Stanford University

    Stanford, United States

    3 h-index

    18 publications

    2K citations

  4. Eterna Massive Open Laboratory

    Stanford, United States

    2 h-index

    16 publications

    1.8K citations

  5. Acuitas Therapeutics (Canada)

    Vancouver, Canada

    2 h-index

    4 publications

    1.1K citations

  6. Harvard University

    Cambridge, United States

    2 h-index

    6 publications

    4.4K citations

  7. Harvard University Press

    Cambridge, United States

    2 h-index

    3 publications

    3.4K citations

  8. CureVac (Germany)

    Tübingen, Germany

    2 h-index

    8 publications

    2.1K citations

1–8 of 57

Venues

  1. Nucleic Acids Research

    4 publications · 1.8K citations

    4

    h-index

  2. Molecular Therapy

    3 publications · 640 citations

    3

    h-index

  3. 2

    h-index

  4. Nature Biotechnology

    2 publications · 549 citations

    2

    h-index

  5. Humana Press eBooks

    Ebook platform · 1 publications · 13 citations

    1

    h-index

1–5