Michael J. Hope

Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution, trapped volume and ability to maintain a membrane potential

Michael J. Hope, Marcel B. Bally, G. A. Webb et al. · Biochimica et Biophysica Acta (BBA) - Biomembranes · 1985 · 2.1K citations

Life Sciences, Biochemistry, Biophysics +13

Rational design of cationic lipids for siRNA delivery

Sean C. Semple, Akin Akinc, Jianxin Chen et al. · Nature Biotechnology · 2010 · 1.8K citations

Pharmacy, Molecular Pharmaceutics, Pharmaceutics +16

Vesicles of variable sizes produced by a rapid extrusion procedure

L.D. Mayer, Michael J. Hope, Pieter R. Cullis · Biochimica et Biophysica Acta (BBA) - Biomembranes · 1986 · 1.7K citations

Engineering, Materials Engineering, Membrane Trafficking +8

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

Akin Akinc, Martin A. Maier, Muthiah Manoharan et al. · Nature Nanotechnology · 2019 · 1.6K citations · Full text

Pharmacy, Molecular Pharmaceutics, Pharmacology +16

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo**

Muthusamy Jayaraman, Steven M. Ansell, Barbara L. Mui et al. · Angewandte Chemie International Edition · 2012 · 1.2K citations · Full text

Pharmacy, Pharmaceutics, Pharmacology +17