Concepedia

Mertk Signaling

MerTK Signaling is a receptor-mediated signal transduction pathway belonging to the TAM (Tyro3, Axl, MerTK) family of receptor tyrosine kinases that specifically regulates the recognition and phagocytic clearance of apoptotic cells by activating downstream anti-inflammatory and efferocytosis-promoting intracellular signals in phagocytes.

226

Publications

19.1K

Citations

1.9K

Authors

551

Institutions

Publications per year

2017–2026

130

Parents

Publications

226

Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways

Won‐Suk Chung, Laura Clarke, Gordon Wang et al. · Nature · 2013 · 1.4K citations · Full text

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Efficient Clearance of Early Apoptotic Cells by Human Macrophages Requires M2c Polarization and MerTK Induction

Gaetano Zizzo, Brendan Hilliard, Marc Monestier et al. · The Journal of Immunology · 2012 · 643 citations · Full text

, , +16

Sleep Loss Promotes Astrocytic Phagocytosis and Microglial Activation in Mouse Cerebral Cortex

Michele Bellesi, Luisa de Vivo, Mattia Chini et al. · Journal of Neuroscience · 2017 · 409 citations · Full text

, , +17

Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP

Yi Zhou, Mingjian Fei, Gu Zhang et al. · Immunity · 2020 · 402 citations · Full text

, , +14

Macrophages and Dendritic Cells Use Different Axl/Mertk/Tyro3 Receptors in Clearance of Apoptotic Cells

Heather Seitz, Todd D. Camenisch, Greg Lemke et al. · The Journal of Immunology · 2007 · 400 citations · Full text

, , +16

1–5 of 226

Authors

1.9K

  1. HS
    H. Shelton Earp

    University of North Carolina at Chapel Hill, United States

    23 publications · 2.2K citations

    23

    h-index

  2. DK
    Douglas K. Graham

    University of North Carolina at Chapel Hill, United States

    18 publications · 1.4K citations

    18

    h-index

  3. DD
    Deborah DeRyckere

    University of North Carolina at Chapel Hill, United States

    13 publications · 747 citations

    13

    h-index

  4. SV
    Stephen V. Frye

    University of North Carolina at Chapel Hill, United States

    13 publications · 765 citations

    13

    h-index

  5. XW
    Xiaodong Wang

    University of North Carolina at Chapel Hill, United States

    12 publications · 734 citations

    12

    h-index

1–5 of 1.9K

Institutions

551

  1. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    24 h-index

    90 publications

    6.5K citations

  2. University of Colorado Denver

    Denver, United States

    13 h-index

    80 publications

    7.4K citations

  3. Yale University

    New Haven, United States

    13 h-index

    58 publications

    6.1K citations

  4. University of Colorado Anschutz Medical Campus

    Aurora, United States

    12 h-index

    53 publications

    3.2K citations

  5. UNC Lineberger Comprehensive Cancer Center

    Chapel Hill, United States

    12 h-index

    36 publications

    4.1K citations

  6. Rutgers, The State University of New Jersey

    New Brunswick, United States

    11 h-index

    88 publications

    7.4K citations

  7. Children's Healthcare of Atlanta

    Atlanta, United States

    9 h-index

    30 publications

    1.6K citations

  8. Emory University

    Atlanta, United States

    8 h-index

    24 publications

    1.1K citations

1–8 of 551

Venues

  1. Frontiers in Immunology

    10 publications · 401 citations

    9

    h-index

  2. PLoS ONE

    8 publications · 288 citations

    8

    h-index

  3. Blood

    7 publications · 821 citations

    7

    h-index

  4. The Journal of Immunology

    JI · 6 publications · 1.3K citations

    6

    h-index

  5. Oncotarget

    6 publications · 178 citations

    6

    h-index

1–5