Concepedia

Mediator Complex Function

Mediator Complex Function is a gene-specific transcriptional regulatory mechanism that serves as a multi-subunit coactivator complex bridging sequence-specific transcription factors with RNA Polymerase II to modulate transcription initiation and elongation through selective recruitment and stabilization of the transcription machinery at promoter regions.

365

Publications

27.3K

Citations

2.3K

Authors

712

Institutions

Publications per year

2017–2026

111

Parents

Publications

365

Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen

Abraham L. Brass, Derek M. Dykxhoorn, Yair Benita et al. · Science · 2008 · 1.4K citations

, , +17

Activating RNAs associate with Mediator to enhance chromatin architecture and transcription

Fan Lai, Matteo Cesaroni, Malte Beringer et al. · Nature · 2013 · 860 citations · Full text

, , +14

<i>MED12</i> , the <i>Mediator Complex Subunit 12</i> Gene, Is Mutated at High Frequency in Uterine Leiomyomas

Netta Mäkinen, Miika Mehine, Jaana Tolvanen et al. · Science · 2011 · 660 citations

, , +17

Integrator, a Multiprotein Mediator of Small Nuclear RNA Processing, Associates with the C-Terminal Repeat of RNA Polymerase II

David Baillat, Mohamed‐Ali Hakimi, Anders M. Näär et al. · Cell · 2005 · 554 citations

, , +17

Quantitative proteomic analysis of distinct mammalian Mediator complexes using normalized spectral abundance factors

Andrew C. Paoletti, Tari Parmely, Chieri Tomomori‐Sato et al. · Proceedings of the National Academy of Sciences · 2006 · 539 citations · Full text

, , +16

1–5 of 365

Authors

2.3K

  1. RG
    Robert G. Roeder

    Rockefeller University, United States

    11 publications · 967 citations

    11

    h-index

  2. CM
    Claes M. Gustafsson

    University of Gothenburg, Sweden

    10 publications · 612 citations

    10

    h-index

  3. LC
    Lawrence C. Myers

    Dartmouth College, United States

    8 publications · 625 citations

    8

    h-index

  4. JK
    Janardan K. Reddy

    Northwestern University, United States

    8 publications · 270 citations

    8

    h-index

  5. YO
    Yoshiaki Ohkuma

    University of Toyama, Japan

    8 publications · 392 citations

    8

    h-index

1–5 of 2.3K

Institutions

712

  1. Rockefeller University

    New York, United States

    15 h-index

    44 publications

    3.5K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    14 h-index

    64 publications

    2.7K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    12 h-index

    40 publications

    16.3K citations

  4. Harvard University

    Cambridge, United States

    11 h-index

    30 publications

    13.4K citations

  5. Chinese Academy of Sciences

    Beijing, China

    10 h-index

    61 publications

    10K citations

  6. Albert Einstein College of Medicine

    Bronx, United States

    9 h-index

    24 publications

    770 citations

  7. Northwestern University

    Evanston, United States

    9 h-index

    44 publications

    1.5K citations

  8. Inserm

    Paris, France

    8 h-index

    36 publications

    1.6K citations

1–8 of 712

Venues

  1. Journal of Biological Chemistry

    JBC · 39 publications · 2.8K citations

    29

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 24 publications · 2.3K citations

    23

    h-index

  3. Molecular and Cellular Biology

    MCB · 25 publications · 1.8K citations

    21

    h-index

  4. Genes & Development

    17 publications · 2.4K citations

    17

    h-index

  5. PLoS ONE

    11 publications · 335 citations

    11

    h-index

1–5