Concepedia

Mechanism-based Combinations

Mechanism-Based Combinations is a therapeutic strategy in oncology that integrates chemotherapeutic agents according to their distinct and complementary molecular mechanisms of action to enhance efficacy, minimize resistance, and reduce overlapping toxicities.

59

Publications

3.1K

Citations

333

Authors

138

Institutions

Publications per year

2017–2026

18

Parents

Publications

59

Mechanism-based in vitro screening of potential cancer chemopreventive agents

Clarissa Gerhäuser, Karin Klimo, Isabell Neumann et al. · Mutation research. Fundamental and molecular mechanisms of mutagenesis · 2003 · 338 citations

, , +10

Pharmacologic Principles of Cancer Treatment.

Annals of Internal Medicine · 1983 · 304 citations

, , +14

Defining principles of combination drug mechanisms of action

Justin R. Pritchard, Peter M. Bruno, Luke A. Gilbert et al. · Proceedings of the National Academy of Sciences · 2012 · 174 citations · Full text

, , +12

Combinatorial effects of thymoquinone on the anti-cancer activity of doxorubicin

Katharina Effenberger‐Neidnicht, Rainer Schobert · Cancer Chemotherapy and Pharmacology · 2010 · 154 citations · Full text

, , +14

Cyclic reactions-mediated self-supply of H2O2 and O2 for cooperative chemodynamic/starvation cancer therapy

Xiaojuan Zhang, Chuanchuan He, Yan Chen et al. · Biomaterials · 2021 · 112 citations

, , +14

1–5 of 59

Authors

333

  1. TH
    Tayyaba Hasan

    Massachusetts General Hospital, United States

    3 publications · 143 citations

    3

    h-index

  2. JB
    Jürgen B. Bulitta

    Monash University, Australia

    3 publications · 109 citations

    3

    h-index

  3. PN
    Patricia N. Holden

    University at Buffalo, State University of New York, United States

    2 publications · 66 citations

    2

    h-index

  4. BT
    Brian T. Tsuji

    University at Buffalo, State University of New York, United States

    2 publications · 66 citations

    2

    h-index

  5. GG
    Gauri G. Rao

    University of North Carolina at Chapel Hill, United States

    2 publications · 66 citations

    2

    h-index

1–5 of 333

Institutions

138

  1. Massachusetts General Hospital

    Boston, United States

    3 h-index

    12 publications

    544 citations

  2. Monash University

    Melbourne, Australia

    3 h-index

    8 publications

    327 citations

  3. University at Buffalo, State University of New York

    Buffalo, United States

    3 h-index

    13 publications

    417 citations

  4. Cornell University

    Ithaca, United States

    3 h-index

    5 publications

    266 citations

  5. University of Florida

    Gainesville, United States

    3 h-index

    3 publications

    109 citations

  6. Memorial Sloan Kettering Cancer Center

    New York, United States

    2 h-index

    3 publications

    140 citations

  7. Sun Yat-sen University

    Guangzhou, China

    2 h-index

    17 publications

    252 citations

  8. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    2 h-index

    2 publications

    81 citations

1–8 of 138

Venues

  1. PubMed

    Repository · 4 publications · 131 citations

    4

    h-index

  2. Antimicrobial Agents and Chemotherapy

    AAC · 2 publications · 65 citations

    2

    h-index

  3. Annals of Internal Medicine

    2 publications · 357 citations

    2

    h-index

  4. Molecular Cancer Therapeutics

    MCT · 2 publications · 121 citations

    2

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 2 publications · 236 citations

    2

    h-index

1–5