Concepedia

Macrolide Interactions

Macrolide Interactions is a pharmacological phenomenon characterized by the inhibition of cytochrome P450-mediated metabolism of immunosuppressive agents, particularly calcineurin inhibitors, by macrolide antibiotics, leading to elevated blood concentrations and increased risk of toxicity in transplant recipients.

53

Publications

2K

Citations

233

Authors

82

Institutions

Publications per year

2017–2026

3

Parents

Publications

53

The Influence of Macrolide Antibiotics on the Uptake of Organic Anions and Drugs Mediated by OATP1B1 and OATP1B3

Annick Seithel, Sonja Eberl, Katrin Singer et al. · Drug Metabolism and Disposition · 2007 · 203 citations

, , +17

The crystal structure of two macrolide glycosyltransferases provides a blueprint for host cell antibiotic immunity

David N. Bolam, S.M. Roberts, Mark R. Proctor et al. · Proceedings of the National Academy of Sciences · 2007 · 157 citations

, , +17

Comparison of the in-vitro effect of several macrolides on the oxidative burst of human neotrophils

M. T. Labro, J. e. Benna, C. Babin-ChevayeC · Journal of Antimicrobial Chemotherapy · 1989 · 93 citations

, , +8

Metabolism of rifabutin in human enterocyte and liver microsomes: Kinetic parameters, identification of enzyme systems, and drug interactions with macrolides and antifungal agents*

Eugenia Iatsimirskaia, Samir Tulebaev, Elena Storozhuk et al. · Clinical Pharmacology & Therapeutics · 1997 · 82 citations

, , +17

Quantitative prediction of macrolide drug-drug interaction potential from in vitro studies using testosterone as the human cytochrome P4503A substrate

Thomas M. Polasek, John O. Miners · European Journal of Clinical Pharmacology · 2006 · 82 citations

, , +17

1–5 of 53

Authors

233

  1. YO
    Yasukiyo Otani

    Oita University, Japan

    2 publications · 34 citations

    2

    h-index

  2. TM
    Takuya Morimoto

    Nara Institute of Science and Technology, Japan

    2 publications · 34 citations

    2

    h-index

  3. JG
    Josyane Gharbi‐Benarous

    Centre National de la Recherche Scientifique, France

    2 publications · 59 citations

    2

    h-index

  4. KT
    Kimiko Tsutsumi

    Oita University, Japan

    2 publications · 34 citations

    2

    h-index

  5. RW
    Ralf Warrassꝉ

    University of Southern Denmark, Denmark

    2 publications · 72 citations

    2

    h-index

1–5 of 233

Institutions

82

  1. Oita University

    Ōita, Japan

    3 h-index

    10 publications

    306 citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    9 publications

    227 citations

  3. The University of Osaka

    Osaka, Japan

    2 h-index

    11 publications

    260 citations

  4. Elanco (United States)

    Greenfield, United States

    2 h-index

    3 publications

    99 citations

  5. Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques

    Paris, France

    2 h-index

    8 publications

    215 citations

  6. GlaxoSmithKline (United Kingdom)

    London, United Kingdom

    2 h-index

    4 publications

    102 citations

  7. University of Alberta

    Edmonton, Canada

    2 h-index

    11 publications

    220 citations

  8. Université Paris Cité

    Paris, France

    2 h-index

    8 publications

    215 citations

1–8 of 82

Venues

  1. Antimicrobial Agents and Chemotherapy

    AAC · 3 publications · 123 citations

    3

    h-index

  2. Journal of Antimicrobial Chemotherapy

    JAC · 3 publications · 135 citations

    3

    h-index

  3. The Journal of Clinical Pharmacology

    2 publications · 34 citations

    2

    h-index

  4. 2

    h-index

  5. Biochemistry

    2 publications · 41 citations

    2

    h-index

1–5