Concepedia

Macrocycle Library Screening

Macrocycle Library Screening is a methodological framework in drug discovery that involves the systematic evaluation of macrocyclic compound libraries to identify structurally and functionally optimized candidates with enhanced binding affinity and selectivity for target biomolecules.

45

Publications

1.6K

Citations

358

Authors

81

Institutions

Publications per year

2017–2026

24

Parents

Publications

45

Discovery of Kinase Spectrum Selective Macrocycle (16<i>E</i>)-14-Methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene (SB1317/TG02), a Potent Inhibitor of Cyclin Dependent Kinases (CDKs), Janus Kinase 2 (JAK2), and Fms-like Tyrosine Kinase-3 (FLT3) for the Treatment of Cancer

Anthony D. William, Angeline C.-H. Lee, Kee Chuan Goh et al. · Journal of Medicinal Chemistry · 2011 · 100 citations · Full text

, , +16

The Discovery of Macrocyclic XIAP Antagonists from a DNA-Programmed Chemistry Library, and Their Optimization To Give Lead Compounds with in Vivo Antitumor Activity

Benjamin A. Seigal, William H. Connors, Andrew W. Fraley et al. · Journal of Medicinal Chemistry · 2015 · 86 citations · Full text

, , +17

Optimization of the Potency and Pharmacokinetic Properties of a Macrocyclic Ghrelin Receptor Agonist (Part I): Development of Ulimorelin (TZP-101) from Hit to Clinic

Hamid R. Hoveyda, Éric Marsault, René Gagnon et al. · Journal of Medicinal Chemistry · 2011 · 82 citations · Full text

, , +17

Template synthesis, spectroscopic studies and biological screening of macrocyclic complexes derived from thiocarbohydrazide and benzil

Dharam Singh, Ramesh Kumar, Parikshit Tyagi · Transition Metal Chemistry · 2006 · 78 citations

, , +17

Display Selection of Exotic Macrocyclic Peptides Expressed under a Radically Reprogrammed 23 Amino Acid Genetic Code

Toby Passioura, Wenyu Liu, Daniel L. Dunkelmann et al. · Journal of the American Chemical Society · 2018 · 75 citations

, , +15

1–5 of 45

Authors

358

  1. JV
    J.-M. Vesin

    École Polytechnique Fédérale de Lausanne, Switzerland

    4 publications · 121 citations

    4

    h-index

  2. PA
    Prabhat Arya

    Steacie Institute for Molecular Sciences, Canada

    4 publications · 66 citations

    4

    h-index

  3. GT
    Gerardo Turcatti

    École Polytechnique Fédérale de Lausanne, Switzerland

    4 publications · 121 citations

    4

    h-index

  4. GC
    Gayathri Chandrasekar

    Karolinska Institutet, Sweden

    4 publications · 66 citations

    4

    h-index

  5. CH
    Christian Heinis

    École Polytechnique Fédérale de Lausanne, Switzerland

    4 publications · 121 citations

    4

    h-index

1–5 of 358

Institutions

81

  1. Karolinska Institutet

    Stockholm, Sweden

    4 h-index

    10 publications

    210 citations

  2. École Polytechnique Fédérale de Lausanne

    Lausanne, Switzerland

    4 h-index

    43 publications

    1.3K citations

  3. Södertörn University

    Huddinge, Sweden

    4 h-index

    13 publications

    252 citations

  4. University of Hyderabad

    Hyderabad, India

    4 h-index

    18 publications

    322 citations

  5. European Centre for Living Technology

    Venice, Italy

    3 h-index

    3 publications

    101 citations

  6. University of Padua

    Padua, Italy

    3 h-index

    3 publications

    101 citations

  7. Scripps Research Institute

    San Diego, United States

    3 h-index

    5 publications

    160 citations

  8. Ca' Foscari University of Venice

    Venice, Italy

    3 h-index

    3 publications

    101 citations

1–8 of 81

Venues

  1. Journal of Medicinal Chemistry

    10 publications · 506 citations

    10

    h-index

  2. Angewandte Chemie International Edition

    3 publications · 77 citations

    3

    h-index

  3. European Journal of Medicinal Chemistry

    3 publications · 99 citations

    3

    h-index

  4. ACS Medicinal Chemistry Letters

    2 publications · 74 citations

    2

    h-index

  5. Journal of the American Chemical Society

    JACS · 2 publications · 101 citations

    2

    h-index

1–5