Concepedia

Lysosomal Translocation

Lysosomal Translocation is a molecular process in chaperone-mediated autophagy whereby cytosolic proteins bearing a KFERQ-like motif are selectively targeted to and translocated across the lysosomal membrane via a luminal-facing chaperone complex, distinguishing it from other degradation pathways by its substrate specificity and lysosome-integrated translocation machinery.

60

Publications

8K

Citations

409

Authors

177

Institutions

Publications per year

2017–2026

21

Parents

Publications

60

Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy

Ana María Cuervo, Leonidas Stefanis, Ross A. Fredenburg et al. · Science · 2004 · 2K citations

, , +17

Dopamine-modified α-synuclein blocks chaperone-mediated autophagy

Marta Martínez‐Vicente, Zsolt Tallóczy, Susmita Kaushik et al. · Journal of Clinical Investigation · 2008 · 625 citations · Full text

, , +17

Activation of Chaperone-mediated Autophagy during Oxidative Stress

Roberta Kiffin, Christopher Christian, Erwin Knecht et al. · Molecular Biology of the Cell · 2004 · 603 citations · Full text

, , +17

Endogenous Drp1 Mediates Mitochondrial Autophagy and Protects the Heart Against Energy Stress

Yoshiyuki Ikeda, Akihiro Shirakabe, Yasuhiro Maejima et al. · Circulation Research · 2014 · 567 citations · Full text

, , +17

A molecular chaperone complex at the lysosomal membrane is required for protein translocation

Fernando A. Agarraberes, J. Fred Dice · Journal of Cell Science · 2001 · 386 citations

, , +17

1–5 of 60

Authors

409

  1. AM
    Ana María Cuervo

    Albert Einstein College of Medicine, United States

    7 publications · 3.6K citations

    7

    h-index

  2. NS
    Noel Southall

    National Institutes of Health, United States

    3 publications · 227 citations

    3

    h-index

  3. WL
    Wendy Lea

    National Institutes of Health, United States

    3 publications · 227 citations

    3

    h-index

  4. EG
    Ehud Goldin

    National Institutes of Health, United States

    3 publications · 227 citations

    3

    h-index

  5. WW
    Wendy Westbroek

    National Human Genome Research Institute, United States

    3 publications · 227 citations

    3

    h-index

1–5 of 409

Institutions

177

  1. Albert Einstein College of Medicine

    Bronx, United States

    9 h-index

    30 publications

    16.6K citations

  2. National Institutes of Health

    Bethesda, United States

    3 h-index

    40 publications

    2.8K citations

  3. National Human Genome Research Institute

    Bethesda, United States

    3 h-index

    24 publications

    1.7K citations

  4. Seoul National University

    Seoul, South Korea

    3 h-index

    4 publications

    149 citations

  5. Brigham and Women's Hospital

    Boston, United States

    2 h-index

    7 publications

    11.2K citations

  6. New York Psychoanalytic Society and Institute

    New York, United States

    2 h-index

    6 publications

    10.6K citations

  7. Hiroshima University

    Hiroshima, Japan

    2 h-index

    13 publications

    492 citations

  8. Institut thématique Génétique, génomique et bioinformatique

    Paris, France

    2 h-index

    2 publications

    127 citations

1–8 of 177

Venues

  1. Autophagy

    7 publications · 491 citations

    7

    h-index

  2. Journal of Biological Chemistry

    JBC · 5 publications · 725 citations

    5

    h-index

  3. Journal of Medicinal Chemistry

    3 publications · 227 citations

    3

    h-index

  4. Cell Reports

    2 publications · 105 citations

    2

    h-index

  5. Cell Death and Disease

    2 publications · 129 citations

    2

    h-index

1–5