Wendy Lea

Fluorescence polarization assays in small molecule screening

Wendy Lea, Anton Simeonov · Expert Opinion on Drug Discovery · 2010 · 371 citations

Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124

Douglas S. Auld, Scott Lovell, Natasha Thorne et al. · Proceedings of the National Academy of Sciences · 2010 · 174 citations · Full text

Chemical Biology, Protein Function, Biochemistry +14

Firefly Luciferase in Chemical Biology: A Compendium of Inhibitors, Mechanistic Evaluation of Chemotypes, and Suggested Use As a Reporter

Natasha Thorne, Min Shen, Wendy Lea et al. · Chemistry & Biology · 2012 · 137 citations · Full text

Biosynthesis, Biochemistry, Firefly Luciferase +8

Discovery, Structure–Activity Relationship, and Biological Evaluation of Noninhibitory Small Molecule Chaperones of Glucocerebrosidase

Samarjit Patnaik, Wei Zheng, Jae Hyuk Choi et al. · Journal of Medicinal Chemistry · 2012 · 132 citations · Full text

Structure–activity Relationship, Glycobiology, Molecular Biology +20

Biochemical, Cellular, and Biophysical Characterization of a Potent Inhibitor of Mutant Isocitrate Dehydrogenase IDH1

Mindy I. Davis, Min Shen, Kimberly Straley et al. · Journal of Biological Chemistry · 2014 · 92 citations · Full text