Concepedia

Luminal Lineage Commitment

Luminal Lineage Commitment is a developmental specification process in mammary stem cell biology in which a multipotent mammary epithelial progenitor cell undergoes lineage restriction to adopt a luminal epithelial cell fate, distinguished from myoepithelial lineage commitment by its activation of luminal-specific gene expression programs and dependence on signaling pathways such as Notch and GATA3.

57

Publications

6.6K

Citations

511

Authors

206

Institutions

Publications per year

2017–2026

14

Parents

Publications

57

Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation

Marie-Liesse Asselin-Labat, Holly E. Barker, Richard M. Thomas et al. · Nature Cell Biology · 2006 · 838 citations

, , +16

GATA-3 Maintains the Differentiation of the Luminal Cell Fate in the Mammary Gland

Hosein Kouros‐Mehr, Euan M. Slorach, Mark D. Sternlicht et al. · Cell · 2006 · 692 citations · Full text

, , +15

Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways

Elgene Lim, Di Wu, Bhupinder Pal et al. · Breast Cancer Research · 2010 · 454 citations · Full text

, , +14

Notch Signaling Regulates Mammary Stem Cell Function and Luminal Cell-Fate Commitment

Toula Bouras, Bhupinder Pal, François Vaillant et al. · Cell stem cell · 2008 · 438 citations · Full text

, , +12

GATA-3 Links Tumor Differentiation and Dissemination in a Luminal Breast Cancer Model

Hosein Kouros‐Mehr, Seth K. Bechis, Euan M. Slorach et al. · Cancer Cell · 2008 · 374 citations · Full text

, , +14

1–5 of 57

Authors

511

  1. JE
    Jane E. Visvader

    Walter and Eliza Hall Institute of Medical Research, Australia

    6 publications · 1.9K citations

    6

    h-index

  2. GJ
    Geoffrey J. Lindeman

    Walter and Eliza Hall Institute of Medical Research, Australia

    5 publications · 1.8K citations

    5

    h-index

  3. FV
    François Vaillant

    Walter and Eliza Hall Institute of Medical Research, Australia

    3 publications · 979 citations

    3

    h-index

  4. MA
    Marie-Liesse Asselin-Labat

    Walter and Eliza Hall Institute of Medical Research, Australia

    3 publications · 1.7K citations

    3

    h-index

  5. TB
    Toula Bouras

    The University of Melbourne, Australia

    3 publications · 943 citations

    3

    h-index

1–5 of 511

Institutions

206

  1. Harvard University

    Cambridge, United States

    9 h-index

    42 publications

    6K citations

  2. Walter and Eliza Hall Institute of Medical Research

    Melbourne, Australia

    7 h-index

    36 publications

    16.6K citations

  3. Dana-Farber Cancer Institute

    Boston, United States

    6 h-index

    32 publications

    5.4K citations

  4. University of Cambridge

    Cambridge, United Kingdom

    6 h-index

    29 publications

    4K citations

  5. Brigham and Women's Hospital

    Boston, United States

    5 h-index

    21 publications

    3.3K citations

  6. Baylor College of Medicine

    Houston, United States

    5 h-index

    13 publications

    646 citations

  7. The University of Melbourne

    Melbourne, Australia

    5 h-index

    15 publications

    4.2K citations

  8. The Royal Melbourne Hospital

    Melbourne, Australia

    4 h-index

    4 publications

    1.7K citations

1–8 of 206

Venues

  1. Oncogene

    5 publications · 333 citations

    5

    h-index

  2. Stem Cells

    5 publications · 258 citations

    5

    h-index

  3. Cancer Cell

    4 publications · 761 citations

    4

    h-index

  4. Cell Reports

    3 publications · 430 citations

    3

    h-index

  5. Stem Cell Reports

    3 publications · 98 citations

    3

    h-index

1–5