Concepedia

Log P Determination

Log P Determination is a quantitative analytical method that belongs to the class of physicochemical measurement techniques, specifically designed to determine the logarithm of the partition coefficient (P) of a compound between immiscible solvents, typically octanol and water, as a measure of its lipophilicity.

124

Publications

8.9K

Citations

453

Authors

173

Institutions

Publications per year

2017–2026

12

Variants

Log P Measurement

Parents

Publications

124

Octanol-Water Partition Coefficients of Simple Organic Compounds

James Sangster · Journal of Physical and Chemical Reference Data · 1989 · 850 citations

, , +10

Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods:  An Analysis of ALOGP and CLOGP Methods

Arup K. Ghose, Vellarkad N. Viswanadhan, John J. Wendoloski · The Journal of Physical Chemistry A · 1998 · 794 citations

, , +17

ElogD<sub>o</sub><sub>ct</sub>:  A Tool for Lipophilicity Determination in Drug Discovery. 2. Basic and Neutral Compounds

Franco Lombardo, Marina Shalaeva, K.A. Tupper et al. · Journal of Medicinal Chemistry · 2001 · 303 citations

, , +15

Calculation of hydrophobic constant (log P) from .pi. and f constants

Albert J. Leo, P. Y. C. JOW, C Silipo et al. · Journal of Medicinal Chemistry · 1975 · 296 citations

, , +8

Computer Automated log P Calculations Based on an Extended Group Contribution Approach

Gilles Klopman, Ju-Yun Li, Shaomeng Wang et al. · Journal of Chemical Information and Computer Sciences · 1994 · 292 citations

, , +6

1–5 of 124

Authors

453

  1. RM
    Raimund Mannhold

    Heinrich Heine University Düsseldorf, Germany

    7 publications · 431 citations

    7

    h-index

  2. PC
    Pierre‐Alain Carrupt

    University of Lausanne, Switzerland

    7 publications · 241 citations

    7

    h-index

  3. MH
    Michael H. Abraham

    University College London, United Kingdom

    5 publications · 554 citations

    5

    h-index

  4. AA
    Alex Avdeef

    Sumitomo Dainippon Pharma (United States), United States

    4 publications · 746 citations

    4

    h-index

  5. IV
    Igor V. Tetko

    Helmholtz Zentrum München, Germany

    4 publications · 428 citations

    4

    h-index

1–5 of 453

Institutions

173

  1. Pfizer (United States)

    New York, United States

    7 h-index

    13 publications

    1.8K citations

  2. University of Lausanne

    Lausanne, Switzerland

    7 h-index

    36 publications

    1.2K citations

  3. Heinrich Heine University Düsseldorf

    Düsseldorf, Germany

    6 h-index

    6 publications

    385 citations

  4. East Sussex County Council

    Lewes, United Kingdom

    6 h-index

    10 publications

    1.7K citations

  5. University College London

    London, United Kingdom

    5 h-index

    14 publications

    2K citations

  6. University of Geneva

    Geneva, Switzerland

    5 h-index

    27 publications

    1K citations

  7. Semmelweis University

    Budapest, Hungary

    4 h-index

    7 publications

    228 citations

  8. Gdańsk Medical University

    Gdansk, Poland

    3 h-index

    9 publications

    576 citations

1–8 of 173

Venues

  1. 10

    h-index

  2. Journal of Medicinal Chemistry

    7 publications · 1K citations

    7

    h-index

  3. Quantitative Structure-Activity Relationships

    7 publications · 453 citations

    7

    h-index

  4. Journal of Pharmaceutical Sciences

    6 publications · 627 citations

    6

    h-index

  5. Journal of Liquid Chromatography

    6 publications · 197 citations

    6

    h-index

1–5