Concepedia

Lipophilicity Reduction

Lipophilicity Reduction is a molecular optimization strategy in drug design that entails decreasing the nonpolar character of a compound to improve its metabolic stability by enhancing aqueous solubility and reducing undesired nonspecific binding.

57

Publications

3.3K

Citations

490

Authors

90

Institutions

Publications per year

2017–2026

19

Parents

Publications

57

Effects of different head groups and functionalised side chains on the aquatic toxicity of ionic liquids

Stefan Stolte, Marianne Matzke, Jürgen Arning et al. · Green Chemistry · 2007 · 531 citations

, , +17

Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development

Jeffrey M. Axten, Stuart P. Romeril, Arthur Y. L. Shu et al. · ACS Medicinal Chemistry Letters · 2013 · 230 citations · Full text

, , +16

Systematic Investigation of Lipophilicity Modulation by Aliphatic Fluorination Motifs

Benjamin Jeffries, Zhong Wang, Hannah R. Felstead et al. · Journal of Medicinal Chemistry · 2020 · 154 citations · Full text

, , +17

Novel Heterocyclic Trans Olefin Analogues of <i>N</i>-{4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butyl}arylcarboxamides as Selective Probes with High Affinity for the Dopamine D3 Receptor

Peter Grundt, Erin E. Carlson, Jianjing Cao et al. · Journal of Medicinal Chemistry · 2005 · 123 citations · Full text

, , +17

Reducing the Lipophilicity of Perfluoroalkyl Groups by CF<sub>2</sub>–F/CF<sub>2</sub>–Me or CF<sub>3</sub>/CH<sub>3</sub> Exchange

Benjamin Jeffries, Zhong Wang, Jérôme Graton et al. · Journal of Medicinal Chemistry · 2018 · 112 citations · Full text

, , +16

1–5 of 57

Authors

490

  1. JS
    James S. Scott

    AstraZeneca (United Kingdom), United Kingdom

    5 publications · 455 citations

    5

    h-index

  2. AS
    Abdelrahman S. Mayhoub

    Al-Azhar University, Egypt

    2 publications · 61 citations

    2

    h-index

  3. HL
    Hank La

    Charles River Laboratories (United Kingdom), United Kingdom

    2 publications · 66 citations

    2

    h-index

  4. ON
    O. N. Zefirova

    Lomonosov Moscow State University, Russia

    2 publications · 23 citations

    2

    h-index

  5. ZW
    Zhong Wang

    University of Southampton, United Kingdom

    2 publications · 266 citations

    2

    h-index

1–5 of 490

Institutions

90

  1. AstraZeneca (United Kingdom)

    Cambridge, United Kingdom

    8 h-index

    31 publications

    2K citations

  2. AstraZeneca (Sweden)

    Södertälje, Sweden

    3 h-index

    38 publications

    1.9K citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    6 publications

    588 citations

  4. Pfizer (United States)

    New York, United States

    3 h-index

    69 publications

    5.5K citations

  5. Purdue University West Lafayette

    West Lafayette, United States

    3 h-index

    10 publications

    265 citations

  6. Nantes Université

    Nantes, France

    2 h-index

    4 publications

    532 citations

  7. National Cancer Institute

    Bethesda, United States

    2 h-index

    19 publications

    394 citations

  8. Zewail City of Science and Technology

    Cairo, Egypt

    2 h-index

    2 publications

    61 citations

1–8 of 90

Venues

  1. Journal of Medicinal Chemistry

    21 publications · 1.3K citations

    19

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    5 publications · 114 citations

    5

    h-index

  3. ACS Medicinal Chemistry Letters

    4 publications · 408 citations

    4

    h-index

  4. Pharmaceutical Research

    2 publications · 120 citations

    2

    h-index

  5. Environmental Toxicology and Chemistry

    2 publications · 142 citations

    2

    h-index

1–5