Concepedia

Lipophilicity Efficiency

Lipophilicity Efficiency is a metric in medicinal chemistry that quantifies the efficiency of a compound's lipophilicity relative to its biological potency, typically expressed as the ratio of potency to lipophilicity, thereby distinguishing it from standalone measures of lipophilicity or activity.

37

Publications

1.7K

Citations

201

Authors

76

Institutions

Publications per year

2017–2026

5

Parents

Publications

37

Impact of Lipophilic Efficiency on Compound Quality

Ákos Tarcsay, Kinga Nyíri, György M. Keserű · Journal of Medicinal Chemistry · 2012 · 160 citations

, , +16

Discovery of a Novel Pyrrole Derivative 1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1<i>H</i>-pyrrol-3-yl]-<i>N</i>-methylmethanamine Fumarate (TAK-438) as a Potassium-Competitive Acid Blocker (P-CAB)

Yasuyoshi Arikawa, Haruyuki Nishida, Osamu Kurasawa et al. · Journal of Medicinal Chemistry · 2012 · 157 citations

, , +17

Validity of Ligand Efficiency Metrics

Christopher W. Murray, Daniel A. Erlanson, Andrew L. Hopkins et al. · ACS Medicinal Chemistry Letters · 2014 · 135 citations · Full text

, , +9

Enhancement of Propranolol Hydrochloride and Diazepam Skin Absorption In Vitro: Effect of Enhancer Lipophilicity

Mltsuhiko Hori, Susumu Satoh, Howard I. Maïbach et al. · Journal of Pharmaceutical Sciences · 1991 · 103 citations

, , +14

The thermodynamic basis for the use of lipophilic efficiency (LipE) in enthalpic optimizations

Michael D. Shultz · Bioorganic & Medicinal Chemistry Letters · 2013 · 98 citations · Full text

, , +14

1–5 of 37

Authors

201

  1. JF
    Jolanta Flieger

    Medical University of Lublin, Poland

    3 publications · 64 citations

    3

    h-index

  2. TK
    Tatsuki Koike

    Takeda (Japan), Japan

    2 publications · 77 citations

    2

    h-index

  3. WR
    William R. Potter

    Roswell Park Comprehensive Cancer Center, United States

    2 publications · 75 citations

    2

    h-index

  4. YC
    Yihui Chen

    Roswell Park Comprehensive Cancer Center, United States

    2 publications · 75 citations

    2

    h-index

  5. JR
    Joseph R. Missert

    Roswell Park Comprehensive Cancer Center, United States

    2 publications · 75 citations

    2

    h-index

1–5 of 201

Institutions

76

  1. Medical University of Lublin

    Lublin, Poland

    4 h-index

    13 publications

    216 citations

  2. Takeda (Japan)

    Osaka, Japan

    3 h-index

    33 publications

    3K citations

  3. Charles University

    Prague, Czechia

    2 h-index

    3 publications

    152 citations

  4. Roswell Park Comprehensive Cancer Center

    Buffalo, United States

    2 h-index

    15 publications

    640 citations

  5. Pfizer (United Kingdom)

    Tadworth, United Kingdom

    2 h-index

    11 publications

    821 citations

  6. University of the Ryukyus

    Okinawa, Japan

    1 h-index

    2 publications

    82 citations

  7. Universidade de São Paulo

    São Paulo, Brazil

    1 h-index

    2 publications

    118 citations

  8. Helmholtz Institute for Pharmaceutical Research Saarland

    Saarbrücken, Germany

    1 h-index

    5 publications

    135 citations

1–8 of 76

Venues

  1. Journal of Medicinal Chemistry

    6 publications · 526 citations

    6

    h-index

  2. 4

    h-index

  3. PubMed

    Repository · 2 publications · 117 citations

    2

    h-index

  4. Molecular Pharmaceutics

    1 publications · 54 citations

    1

    h-index

  5. Small

    1 publications · 48 citations

    1

    h-index

1–5