Concepedia

Ligand-directed Uptake

Ligand-Directed Uptake is a cellular drug uptake mechanism in which the selective internalization of therapeutic agents into target cells is mediated by the specific binding of a ligand to a cognate receptor on the cell surface, thereby enabling receptor-mediated endocytosis distinct from passive diffusion or nonspecific uptake processes.

26

Publications

1.1K

Citations

114

Authors

45

Institutions

Publications per year

2017–2026

2

Parents

Publications

26

Internalization and degradation of macrophage Fc receptors bound to polyvalent immune complexes.

Ira Mellman, Helen Plutner · The Journal of Cell Biology · 1984 · 255 citations · Full text

, , +17

Rate of internalization of an immunotoxin correlates with cytotoxic activity against human tumor cells.

U. WARGALLA, R. Reisfeld · Proceedings of the National Academy of Sciences · 1989 · 86 citations · Full text

, , +10

H-2D Ligand Expression by Ly49A<b>+</b> Natural Killer (NK) Cells Precludes Ligand Uptake from Environmental Cells

Jacques Zimmer, Vassilios Ioannidis, Werner Held · The Journal of Experimental Medicine · 2001 · 76 citations · Full text

, , +17

Recycling of the Yeast <b>a</b>-Factor Receptor

Linyi Chen, Nicholas G. Davis · The Journal of Cell Biology · 2000 · 64 citations · Full text

, , +17

Drug Uptake Pathways of Multidrug Transporter AcrB Studied by Molecular Simulations and Site-Directed Mutagenesis Experiments

Xin‐Qiu Yao, Nobuhiro Kimura, Satoshi Murakami et al. · Journal of the American Chemical Society · 2013 · 56 citations

, , +14

1–5 of 26

Authors

114

  1. KL
    Kanak L. Dikshit

    Institute of Microbial Technology, India

    2 publications · 23 citations

    2

    h-index

  2. IB
    Ignacio Borón

    Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina

    2 publications · 23 citations

    2

    h-index

  3. RR
    Rafael Radí

    Universidad de la República de Uruguay, Uruguay

    2 publications · 23 citations

    2

    h-index

  4. LB
    Leonardo Boechi

    Universidad de Buenos Aires, Argentina

    2 publications · 23 citations

    2

    h-index

  5. AA
    Aintzane Asumendi

    University of the Basque Country, Spain

    2 publications · 59 citations

    2

    h-index

1–5 of 114

Institutions

45

  1. University of Oxford

    Oxford, United Kingdom

    3 h-index

    5 publications

    167 citations

  2. University of Sheffield

    Sheffield, United Kingdom

    2 h-index

    4 publications

    46 citations

  3. Universidad de Buenos Aires

    Buenos Aires, Argentina

    2 h-index

    10 publications

    115 citations

  4. Universidad de la República de Uruguay

    Montevideo, Uruguay

    2 h-index

    4 publications

    46 citations

  5. Consejo Nacional de Investigaciones Científicas y Técnicas

    Buenos Aires, Argentina

    2 h-index

    4 publications

    46 citations

  6. Fundación Ciencias Exactas y Naturales

    Buenos Aires, Argentina

    2 h-index

    10 publications

    115 citations

  7. University of the Basque Country

    Leioa, Spain

    2 h-index

    6 publications

    171 citations

  8. University of Nottingham

    Nottingham, United Kingdom

    2 h-index

    2 publications

    23 citations

1–8 of 45

Venues

  1. PubMed

    Repository · 3 publications · 58 citations

    3

    h-index

  2. Journal of Biological Chemistry

    JBC · 2 publications · 76 citations

    2

    h-index

  3. The Journal of Cell Biology

    JCB · 2 publications · 319 citations

    2

    h-index

  4. Hepatology

    2 publications · 59 citations

    2

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 2 publications · 105 citations

    2

    h-index

1–5