Library-based Antibody Selection

Library-Based Antibody Selection is a methodological framework in antibody engineering that employs diverse molecular libraries of antibody variants to identify specific binders through high-throughput screening and selection techniques, distinguished by its reliance on combinatorial display platforms such as phage, yeast, or ribosome display to isolate antibodies with desired antigen specificity.

203

Publications

11.1K

Citations

1.2K

Authors

328

Institutions

Publications per year

2017–2026

Variants

Antibody Library Selection

Parents

Antibody Specificity Engineering

Publications

203

A large array of human monoclonal antibodies to type 1 human immunodeficiency virus from combinatorial libraries of asymptomatic seropositive individuals.

Dennis R. Burton, Carlos F. Barbas, Mats A. A. Persson et al. · Proceedings of the National Academy of Sciences · 1991 · 658 citations

Pharmacy, Biotechnology, Immunology +17

Selection of antibody ligands from a large library of oligopeptides expressed on a multivalent exposition vector

Franco Felici, Luisa Castagnoli, Roberto Jappelli et al. · Journal of Molecular Biology · 1991 · 398 citations

Pharmacy, Biochemistry, Immunology +16

Antibody-ribosome-mRNA (ARM) complexes as efficient selection particles for in vitro display and evolution of antibody combining sites

M. He · Nucleic Acids Research · 1997 · 267 citations · Full text

Pharmacy, Biotechnology, Molecular Biology +17

The Human Combinatorial Antibody Library HuCAL GOLD Combines Diversification of All Six CDRs According to the Natural Immune System with a Novel Display Method for Efficient Selection of High-Affinity Antibodies

Christine Rothe, Stefanie Urlinger, Corinna Löhning et al. · Journal of Molecular Biology · 2008 · 246 citations

Pharmacy, Biotechnology, Immunology +17

Clinical evidence of efficient tumor targetting based on single–chain Fv antibody selected from a combinatorial library

Richard H. J. Beǵent, Marlies J. Verhaar, Kerry Chester et al. · Nature Medicine · 1996 · 242 citations

Pharmacy, Immunology, Oncology +17

1–5 of 203

Authors

1.2K

CF
Carlos F. Barbas
Scripps Research Institute, United States
7 publications · 1.2K citations
7
h-index
RA
Richard A. Lerner
Scripps Research Institute, United States
6 publications · 550 citations
6
h-index
JD
James D. Marks
University of California, San Francisco, United States
6 publications · 474 citations
6
h-index
CG
Changshou Gao
Scripps Research Institute, United States
5 publications · 372 citations
5
h-index
AB
Andrew Bradbury
Los Alamos National Laboratory, United States
5 publications · 389 citations
5
h-index

1–5 of 1.2K

Institutions

328

1–8 of 328

Venues

Journal of Immunological Methods
23 publications · 1K citations
17
h-index
Journal of Molecular Biology
JMB · 17 publications · 2K citations
16
h-index
Methods in molecular biology
Book series · 12 publications · 367 citations
12
h-index
Proceedings of the National Academy of Sciences
PNAS · 9 publications · 1.5K citations
9
h-index
Biochemical and Biophysical Research Communications
BBRC · 5 publications · 245 citations
5
h-index

1–5