Concepedia

Lag-2 Ligands

Lag-2 Ligands is a transmembrane signaling protein in the Notch signaling pathway that functions as a canonical ligand by binding to Notch receptors to initiate cell fate determination through juxtacrine communication.

21

Publications

2.3K

Citations

105

Authors

27

Institutions

Publications per year

2017–2026

2

Variants

Lag-2

Parents

Publications

21

<i>lag-2</i> may encode a signaling ligand for the GLP-1 and LIN-12 receptors of <i>C. elegans</i>

Samuel T. Henderson, Dali Gao, Eric J. Lambie et al. · Development · 1994 · 397 citations

, , +16

Sequence of C. elegans lag-2 reveals a cell-signalling domain shared with Delta and Serrate of Drosophila

Frans E. Tax, Jon J. Yeargers, James H. Thomas · Nature · 1994 · 258 citations

, , +9

Mouse Jagged1 Physically Interacts with Notch2 and Other Notch Receptors

Kiyoshí Shimizu, Shigeru Chiba, Keiki Kumano et al. · Journal of Biological Chemistry · 1999 · 249 citations · Full text

, , +16

The possible correlation of Notch-1 and Notch-2 with clinical outcome and tumour clinicopathological parameters in human breast cancer

Callum Parr, Gareth M. Watkins, Wen G. Jiang · International Journal of Molecular Medicine · 2004 · 231 citations

, , +17

Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2

Kiyoshí Shimizu, Shigeru Chiba, Noriko Hosoya et al. · Molecular and Cellular Biology · 2000 · 162 citations

, , +13

1–5 of 21

Authors

105

  1. HH
    Hisamaru Hirai

    The University of Tokyo, Japan

    3 publications · 531 citations

    3

    h-index

  2. PA
    Penny A. Handford

    University of Oxford, United Kingdom

    3 publications · 152 citations

    3

    h-index

  3. SC
    Shigeru Chiba

    The University of Tokyo, Japan

    3 publications · 531 citations

    3

    h-index

  4. KK
    Keiki Kumano

    The University of Tokyo, Japan

    3 publications · 531 citations

    3

    h-index

  5. IG
    Iva Greenwald

    Columbia University, United States

    3 publications · 302 citations

    3

    h-index

1–5 of 105

Institutions

27

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    4 h-index

    8 publications

    698 citations

  2. The University of Tokyo

    Tokyo, Japan

    3 h-index

    22 publications

    4K citations

  3. Columbia University

    New York, United States

    3 h-index

    6 publications

    604 citations

  4. University of Oxford

    Oxford, United Kingdom

    3 h-index

    28 publications

    1.4K citations

  5. National Institute for Basic Biology

    Okazaki, Japan

    2 h-index

    2 publications

    411 citations

  6. Air Force Medical University

    Xi'an, China

    2 h-index

    22 publications

    514 citations

  7. Xijing Hospital

    Xi’an, China

    1 h-index

    3 publications

    66 citations

  8. University of Washington

    Seattle, United States

    1 h-index

    3 publications

    774 citations

1–8 of 27

Venues

  1. Journal of Biological Chemistry

    JBC · 3 publications · 484 citations

    3

    h-index

  2. Development

    2 publications · 557 citations

    2

    h-index

  3. Science China Life Sciences

    1 publications · 22 citations

    1

    h-index

  4. Genetics

    1 publications · 48 citations

    1

    h-index

  5. Cell Reports

    1 publications · 63 citations

    1

    h-index

1–5