Notch2 Is Preferentially Expressed in Mature B Cells and Indispensable for Marginal Zone B Lineage Development

Shigeru Chiba, Motoshi Ichikawa, Atsushi Kunisato, +10

Immunity

Cell LineageLineage PlasticityDevelopmental BiologyCell RegulationMature B Cells +8

Notch1 but Not Notch2 Is Essential for Generating Hematopoietic Stem Cells from Endothelial Cells

Keiki Kumano, Shigeru Chiba, Atsushi Kunisato, +9

Immunity

Developmental BiologyEndothelial CellsMedicineHematologyBlood Cell +5

Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms

Masashi Sanada, Takahiro Suzuki, Lee‐Yung Shih, +26

Nature

Hematological MalignancyMyeloid NeoplasmsMedicineCell BiologyCancer Research +2

Mouse Jagged1 Physically Interacts with Notch2 and Other Notch Receptors

Kiyoshí Shimizu, Shigeru Chiba, Keiki Kumano, +6

Journal of Biological Chemistry

Positive feedback between NF-κB and TNF-α promotes leukemia-initiating cell capacity

Yuki Kagoya, Akihide Yoshimi, Keisuke Kataoka, +7

Journal of Clinical Investigation

Positive FeedbackImmunologyImmune RegulationCell DeathLeukemia Progression +19

Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity

Keisuke Kataoka, Tomohiko Sato, Akihide Yoshimi, +12

The Journal of Experimental Medicine

Adult Bone MarrowCell LineageDevelopmental BiologyHealth SciencesMedicine +12

Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2

Kiyoshí Shimizu, Shigeru Chiba, Noriko Hosoya, +5

Molecular and Cellular Biology

Gain‐of‐function mutations and copy number increases of Notch2 in diffuse large B‐cell lymphoma

Suk‐young Lee, Keiki Kumano, Kumi Nakazaki, +16

Cancer Science

Copy Number IncreasesLymphoid NeoplasiaHematological MalignancyNotch2 ProteinNotch2 Mutations +11

Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples

Keiki Kumano, Shunya Arai, Masataka Hosoi, +11

Blood

HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo

Atsushi Kunisato, Shigeru Chiba, Etsuko Nakagami‐Yamaguchi, +8

Blood