Concepedia

Knowledge Graph-based Repurposing

Knowledge Graph-Based Repurposing is a computational approach within drug repurposing that leverages structured knowledge graphs—integrating heterogeneous biological, chemical, and phenotypic data through semantic relationships—to systematically identify novel therapeutic indications for existing drugs by inferring non-obvious connections between drugs, targets, and diseases.

74

Publications

4.3K

Citations

468

Authors

189

Institutions

Publications per year

2017–2026

72

Variants

Knowledge Graph-based Drug Repurposing

Parents

Publications

74

Systematic integration of biomedical knowledge prioritizes drugs for repurposing

Daniel Himmelstein, Antoine Lizée, Christine Hessler et al. · eLife · 2017 · 617 citations · Full text

, , +17

Utilizing graph machine learning within drug discovery and development

Thomas Gaudelet, Ben Day, Arian R. Jamasb et al. · Briefings in Bioinformatics · 2021 · 282 citations · Full text

, , +17

Repurpose Open Data to Discover Therapeutics for COVID-19 Using Deep Learning

Xiangxiang Zeng, Xiang Song, Tengfei Ma et al. · Journal of Proteome Research · 2020 · 264 citations · Full text

, , +17

Drug repurposing for COVID-19 via knowledge graph completion

Rui Zhang, Dimitar Hristovski, Dalton Schutte et al. · Journal of Biomedical Informatics · 2021 · 208 citations · Full text

, , +12

Deep learning for drug repurposing: Methods, databases, and applications

Xiaoqin Pan, Xuan Lin, Dongsheng Cao et al. · Wiley Interdisciplinary Reviews Computational Molecular Science · 2022 · 175 citations

, , +16

1–5 of 74

Authors

468

  1. FC
    Feixiong Cheng

    Cleveland Clinic Lerner College of Medicine, United States

    4 publications · 479 citations

    4

    h-index

  2. RZ
    Rui Zhang

    University of Minnesota, United States

    4 publications · 287 citations

    4

    h-index

  3. XZ
    Xiangxiang Zeng

    Hunan University, China

    3 publications · 450 citations

    3

    h-index

  4. GK
    George Karypis

    University of Minnesota, United States

    3 publications · 318 citations

    3

    h-index

  5. CC
    Chao Che

    Dalian University of Technology, China

    3 publications · 147 citations

    3

    h-index

1–5 of 468

Institutions

189

  1. University of Minnesota

    Minneapolis, United States

    5 h-index

    12 publications

    883 citations

  2. Case Western Reserve University

    Cleveland, United States

    5 h-index

    9 publications

    801 citations

  3. The University of Texas Health Science Center at Houston

    Houston, United States

    4 h-index

    24 publications

    888 citations

  4. University of Pennsylvania

    Philadelphia, United States

    4 h-index

    11 publications

    1.6K citations

  5. Stanford University

    Stanford, United States

    4 h-index

    15 publications

    1.2K citations

  6. Cornell University

    Ithaca, United States

    4 h-index

    15 publications

    479 citations

  7. Inserm

    Paris, France

    4 h-index

    7 publications

    811 citations

  8. University of Illinois Urbana-Champaign

    Urbana, United States

    3 h-index

    17 publications

    1.8K citations

1–8 of 189

Venues

  1. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 6 publications · 330 citations

    6

    h-index

  2. Scientific Reports

    6 publications · 199 citations

    6

    h-index

  3. arXiv (Cornell University)

    Repository · 4 publications · 92 citations

    4

    h-index

  4. Bioinformatics

    4 publications · 113 citations

    4

    h-index

  5. BMC Bioinformatics

    3 publications · 66 citations

    3

    h-index

1–5