Concepedia

Knock-in Strategy

Knock-In Strategy is a genome integration strategy that involves the targeted insertion of an exogenous DNA sequence into a specific genomic locus to achieve precise genetic modification, thereby enabling the controlled expression of a gene or regulatory element at a defined site.

69

Publications

5.3K

Citations

561

Authors

207

Institutions

Publications per year

2017–2026

34

Variants

Knock-in

Parents

Publications

69

Ginger‐derived nanoparticles protect against alcohol‐induced liver damage

Xiaoying Zhuang, Zhongbin Deng, Jingyao Mu et al. · Journal of Extracellular Vesicles · 2015 · 577 citations · Full text

, , +17

A library of MiMICs allows tagging of genes and reversible, spatial and temporal knockdown of proteins in Drosophila

Sonal Nagarkar-Jaiswal, Pei-Tseng Lee, Megan E. Campbell et al. · eLife · 2015 · 462 citations · Full text

, , +12

Nuclear domain ‘knock-in’ screen for the evaluation and identification of small molecule enhancers of CRISPR-based genome editing

Jordan Pinder, Jayme Salsman, Graham Dellaire · Nucleic Acids Research · 2015 · 290 citations · Full text

, , +16

Ventricular muscle-restricted targeting of the RXRα gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis

Ju Chen, Steven W. Kubalak, Kenneth R. Chien · Development · 1998 · 289 citations

, , +15

Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinase

Gunhild Sommer, Valter Agosti, Imke Ehlers et al. · Proceedings of the National Academy of Sciences · 2003 · 243 citations · Full text

, , +17

1–5 of 69

Authors

561

  1. DN
    David N. Nguyen

    University of California, San Francisco, United States

    2 publications · 205 citations

    2

    h-index

  2. TL
    Theodore L. Roth

    University of California, San Francisco, United States

    2 publications · 205 citations

    2

    h-index

  3. JC
    Ju Chen

    University of California San Diego, United States

    2 publications · 503 citations

    2

    h-index

  4. KA
    Kimi Araki

    Kumamoto University, Japan

    2 publications · 86 citations

    2

    h-index

  5. AM
    Alexander Marson

    University of California, San Francisco, United States

    2 publications · 205 citations

    2

    h-index

1–5 of 561

Institutions

207

  1. Chinese Academy of Sciences

    Beijing, China

    3 h-index

    18 publications

    1.1K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    15 publications

    1.3K citations

  3. Mayo Clinic in Arizona

    Scottsdale, United States

    2 h-index

    12 publications

    1.3K citations

  4. University of California San Diego

    San Diego, United States

    2 h-index

    4 publications

    1K citations

  5. UCSF Helen Diller Family Comprehensive Cancer Center

    San Francisco, United States

    2 h-index

    5 publications

    426 citations

  6. Ludwig-Maximilians-Universität München

    Munich, Germany

    2 h-index

    2 publications

    85 citations

  7. University Medical Center Utrecht

    Utrecht, The Netherlands

    2 h-index

    2 publications

    51 citations

  8. Kumamoto University

    Kumamoto, Japan

    2 h-index

    2 publications

    86 citations

1–8 of 207

Venues

  1. Scientific Reports

    5 publications · 258 citations

    5

    h-index

  2. Development

    4 publications · 553 citations

    4

    h-index

  3. International Journal of Molecular Sciences

    IJMS · 3 publications · 175 citations

    3

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 468 citations

    3

    h-index

  5. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 2 publications · 44 citations

    2

    h-index

1–5