Concepedia

Kit Signaling

Kit Signaling is a receptor tyrosine kinase signaling pathway mediated by the c-Kit receptor, distinguished by its activation through stem cell factor binding and its critical role in regulating cell survival, proliferation, and differentiation in hematopoietic, mast, and gastrointestinal progenitor cells.

789

Publications

78.3K

Citations

4.6K

Authors

1.1K

Institutions

Publications per year

2017–2026

86

Variants

C-kit Signaling

Parents

Publications

789

Gain-of-Function Mutations of c- <i>kit</i> in Human Gastrointestinal Stromal Tumors

Seiichi Hirota, Koji Isozaki, Y Moriyama et al. · Science · 1998 · 4.5K citations

, , +17

<i>PDGFRA</i> Activating Mutations in Gastrointestinal Stromal Tumors

Michael C. Heinrich, Christopher L. Corless, Anette Duensing et al. · Science · 2003 · 2.3K citations

, , +17

Human proto‐oncogene c‐kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.

Yosef Yarden, Wun-Jing Kuang, Teresa L. Yang‐Feng et al. · The EMBO Journal · 1987 · 1.6K citations · Full text

, , +13

Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor

Krisztina M. Zsebo, David A. Williams, E N Geissler et al. · Cell · 1990 · 1.4K citations

, , +14

The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus

Benoı̂t Chabot, Dennis A. Stephenson, Verne M. Chapman et al. · Nature · 1988 · 1.4K citations

, , +12

1–5 of 789

Authors

4.6K

  1. PB
    Peter Besmer

    Kettering University, United States

    35 publications · 8.2K citations

    32

    h-index

  2. LR
    Lars Rönnstrand

    Lund University, Sweden

    20 publications · 1.6K citations

    18

    h-index

  3. SH
    Seiichi Hirota

    Hyogo Medical University, Japan

    16 publications · 6K citations

    16

    h-index

  4. YK
    Yukihiko Kitamura

    The University of Osaka, Japan

    17 publications · 6.3K citations

    15

    h-index

  5. YK
    Yuzuru Kanakura

    The University of Osaka, Japan

    14 publications · 5.7K citations

    13

    h-index

1–5 of 4.6K

Institutions

1.1K

  1. The University of Osaka

    Osaka, Japan

    29 h-index

    252 publications

    89.9K citations

  2. Memorial Sloan Kettering Cancer Center

    New York, United States

    24 h-index

    184 publications

    31.7K citations

  3. Kettering University

    Flint, United States

    23 h-index

    99 publications

    21K citations

  4. Cornell University

    Ithaca, United States

    22 h-index

    104 publications

    22.6K citations

  5. Harvard University

    Cambridge, United States

    20 h-index

    81 publications

    19.5K citations

  6. Brigham and Women's Hospital

    Boston, United States

    20 h-index

    74 publications

    17.9K citations

  7. Indiana University – Purdue University Indianapolis

    Indianapolis, United States

    18 h-index

    105 publications

    6.9K citations

  8. Inserm

    Paris, France

    17 h-index

    100 publications

    8K citations

1–8 of 1.1K

Venues

  1. Blood

    99 publications · 10K citations

    55

    h-index

  2. PubMed

    Repository · 73 publications · 7K citations

    44

    h-index

  3. Journal of Biological Chemistry

    JBC · 31 publications · 3.5K citations

    28

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 21 publications · 4.6K citations

    20

    h-index

  5. Development

    18 publications · 3.6K citations

    18

    h-index

1–5