Concepedia

Intestinal First-pass Extraction

Intestinal First-Pass Extraction is a pharmacokinetic process in which an orally administered drug undergoes significant enzymatic metabolism within the intestinal wall during absorption, thereby reducing its systemic bioavailability before reaching the hepatic circulation.

47

Publications

4K

Citations

191

Authors

65

Institutions

Publications per year

2017–2026

0

Parents

Publications

47

Uptake and Metabolism of Plasma Glutamine by the Small Intestine

H.G. Windmueller, Albert E. Spaeth · Journal of Biological Chemistry · 1974 · 791 citations · Full text

, , +11

Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism*

Kenneth E. Thummel, Diarmuid O’Shea, Mary F. Paine et al. · Clinical Pharmacology & Therapeutics · 1996 · 619 citations

, , +17

Differentiation of absorption and first-pass gut and hepatic metabolism in humans: Studies with cyclosporine*

Chi-Yuan Wu, Leslie Z. Benet, Mary F. Hébert et al. · Clinical Pharmacology & Therapeutics · 1995 · 356 citations

, , +17

Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction

K Thummel · Advanced Drug Delivery Reviews · 1997 · 316 citations

, , +14

Gene and Protein Expression of P-Glycoprotein, MRP1, MRP2, and CYP3A4 in the Small and Large Human Intestine

Sofia Berggren, Christine M. Gall, Nadine Wollnitz et al. · Molecular Pharmaceutics · 2007 · 211 citations

, , +17

1–5 of 47

Authors

191

  1. MF
    Mary F. Paine

    Washington State University Spokane, United States

    4 publications · 804 citations

    4

    h-index

  2. KE
    Kenneth E. Thummel

    University of Washington, United States

    4 publications · 822 citations

    4

    h-index

  3. KL
    Kent L. Kunze

    University of Washington, United States

    3 publications · 774 citations

    3

    h-index

  4. YH
    Yukiya Hashimoto

    Kyoto University Hospital, Japan

    3 publications · 47 citations

    3

    h-index

  5. JN
    J. Noordhoek

    Utrecht University, Netherlands

    3 publications · 78 citations

    3

    h-index

1–5 of 191

Institutions

65

  1. University of Washington

    Seattle, United States

    5 h-index

    21 publications

    5.7K citations

  2. Uppsala University

    Uppsala, Sweden

    3 h-index

    11 publications

    1.8K citations

  3. AstraZeneca (Sweden)

    Södertälje, Sweden

    2 h-index

    13 publications

    1.9K citations

  4. Pharmac

    Wellington, New Zealand

    2 h-index

    2 publications

    33 citations

  5. Nagoya City University

    Nagoya, Japan

    2 h-index

    6 publications

    162 citations

  6. Tohoku Medical and Pharmaceutical University

    Sendai, Japan

    2 h-index

    7 publications

    109 citations

  7. Rutgers, The State University of New Jersey

    New Brunswick, United States

    2 h-index

    6 publications

    156 citations

  8. University of Minnesota

    Minneapolis, United States

    2 h-index

    2 publications

    33 citations

1–8 of 65

Venues

  1. Drug Metabolism and Disposition

    11 publications · 255 citations

    11

    h-index

  2. 7

    h-index

  3. Clinical Pharmacology & Therapeutics

    CPT · 4 publications · 1.2K citations

    4

    h-index

  4. PubMed

    Repository · 3 publications · 153 citations

    3

    h-index

  5. Drug Metabolism and Pharmacokinetics

    DMPK · 3 publications · 64 citations

    3

    h-index

1–5