Concepedia

Interface Specificity Evolution

Interface Specificity Evolution is a theoretical construct in protein interface evolution that characterizes the selective refinement of molecular interaction preferences at protein-protein interfaces over evolutionary time, distinguishing it from broader interface evolution mechanisms by focusing exclusively on the emergence and optimization of binding specificity.

8

Publications

832

Citations

37

Authors

22

Institutions

Publications per year

2017–2026

1

Parents

Publications

8

Evolving New Protein-Protein Interaction Specificity through Promiscuous Intermediates

Christopher D. Aakre, Julien Herrou, Tuyen N. Phung et al. · Cell · 2015 · 228 citations

, , +14

Protein interactions and ligand binding: From protein subfamilies to functional specificity

Antonio Rausell, David Juan, Florencio Pazos et al. · Proceedings of the National Academy of Sciences · 2010 · 151 citations · Full text

, , +16

Intermolecular epistasis shaped the function and evolution of an ancient transcription factor and its DNA binding sites

Dave W. Anderson, Alesia N. McKeown, Joseph W. Thornton · eLife · 2015 · 116 citations · Full text

, , +17

Design of Multi-Specificity in Protein Interfaces

Tanja Kortemme · PLoS Computational Biology · 2007 · 107 citations · Full text

, , +17

Following evolutionary paths to protein-protein interactions with high affinity and selectivity

Kalia Bernath-Levin, Orly Dym, Shira Albeck et al. · Nature Structural & Molecular Biology · 2009 · 90 citations

, , +16

1–5 of 8

Authors

37

  1. EW
    Elliot W. Chan

    University of York, United Kingdom

    1 publications · 45 citations

    1

    h-index

  2. XT
    Xiao Tan

    The University of Queensland, Australia

    1 publications · 45 citations

    1

    h-index

  3. JS
    Javier Sancho

    Universidad de Zaragoza, Spain

    1 publications · 13 citations

    1

    h-index

  4. BC
    Bruno Contreras‐Moreira

    Estación Experimental de Aula Dei, Spain

    1 publications · 13 citations

    1

    h-index

  5. DM
    David M. Lawson

    John Innes Centre, United Kingdom

    1 publications · 45 citations

    1

    h-index

1–5 of 37

Institutions

22

  1. Massachusetts Institute of Technology

    Cambridge, United States

    2 h-index

    5 publications

    994 citations

  2. University of York

    York, United Kingdom

    2 h-index

    4 publications

    270 citations

  3. University of Chicago

    Chicago, United States

    2 h-index

    3 publications

    572 citations

  4. Center for Systems Biology

    Boston, United States

    1 h-index

    1 publications

    82 citations

  5. Howard Hughes Medical Institute

    Chevy Chase, United States

    1 h-index

    1 publications

    228 citations

  6. Universidad de Zaragoza

    Zaragoza, Spain

    1 h-index

    3 publications

    39 citations

  7. University of Leicester

    Leicester, United Kingdom

    1 h-index

    1 publications

    90 citations

  8. Weizmann Institute of Science

    Rehovot, Israel

    1 h-index

    4 publications

    360 citations

1–8 of 22

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 2 publications · 233 citations

    2

    h-index

  2. Nature Structural & Molecular Biology

    1 publications · 90 citations

    1

    h-index

  3. eLife

    1 publications · 116 citations

    1

    h-index

  4. PLoS Computational Biology

    1 publications · 107 citations

    1

    h-index

  5. Cell Reports

    1 publications · 45 citations

    1

    h-index

1–5