Concepedia

Inside-out Integrin Activation

Inside-Out Integrin Activation is a signaling mechanism in cell biology whereby intracellular signals initiate conformational changes in integrin receptors, thereby increasing their affinity for extracellular ligands and facilitating platelet adhesion and aggregation.

111

Publications

10.2K

Citations

561

Authors

196

Institutions

Publications per year

2017–2026

10

Parents

Publications

111

Global Conformational Rearrangements in Integrin Extracellular Domains in Outside-In and Inside-Out Signaling

Junichi Takagi, Benjamin M. Petre, Thomas Walz et al. · Cell · 2002 · 1.2K citations · Full text

, , +16

Bidirectional Transmembrane Signaling by Cytoplasmic Domain Separation in Integrins

Minsoo Kim, Christopher V. Carman, Timothy A. Springer · Science · 2003 · 779 citations

, , +17

Integrin cytoplasmic domains mediate inside-out signal transduction

TE O'Toole, Yasuhiro Katagiri, RJ Faull et al. · The Journal of Cell Biology · 1994 · 672 citations · Full text

, , +13

A Structural Mechanism of Integrin αIIbβ3 “Inside-Out” Activation as Regulated by Its Cytoplasmic Face

Olga Vinogradova, Algirdas Vėlyvis, Asta Velyviene et al. · Cell · 2002 · 524 citations · Full text

, , +14

The structure of an integrin/talin complex reveals the basis of inside‐out signal transduction

Nicholas J. Anthis, Kate L. Wegener, Feng Ye et al. · The EMBO Journal · 2009 · 344 citations · Full text

, , +14

1–5 of 111

Authors

561

  1. TA
    Timothy A. Springer

    Harvard University, United States

    8 publications · 2.8K citations

    8

    h-index

  2. SJ
    Sanford J. Shattil

    Scripps Research Institute, United States

    6 publications · 1K citations

    6

    h-index

  3. MH
    Mark H. Ginsberg

    University of California San Diego, United States

    6 publications · 1.2K citations

    6

    h-index

  4. EF
    Edward F. Plow

    Cleveland Clinic, United States

    5 publications · 1.1K citations

    5

    h-index

  5. JZ
    Jieqing Zhu

    Versiti Blood Center of Wisconsin, United States

    5 publications · 252 citations

    5

    h-index

1–5 of 561

Institutions

196

  1. Harvard University

    Cambridge, United States

    10 h-index

    45 publications

    9.3K citations

  2. University of Pennsylvania

    Philadelphia, United States

    8 h-index

    17 publications

    2.2K citations

  3. Scripps Research Institute

    San Diego, United States

    7 h-index

    39 publications

    12.1K citations

  4. Versiti Blood Center of Wisconsin

    Milwaukee, United States

    5 h-index

    20 publications

    1.2K citations

  5. University of California San Diego

    San Diego, United States

    5 h-index

    11 publications

    1.8K citations

  6. The Honourable Society of Lincoln's Inn

    London, United Kingdom

    5 h-index

    12 publications

    1.1K citations

  7. University of Helsinki

    Helsinki, Finland

    4 h-index

    9 publications

    786 citations

  8. Dana-Farber/Boston Children's Cancer and Blood Disorders Center

    Boston, United States

    4 h-index

    8 publications

    3.5K citations

1–8 of 196

Venues

  1. Journal of Biological Chemistry

    JBC · 19 publications · 1.5K citations

    16

    h-index

  2. The Journal of Cell Biology

    JCB · 6 publications · 1.1K citations

    6

    h-index

  3. Blood

    6 publications · 483 citations

    6

    h-index

  4. Journal of Cell Science

    6 publications · 321 citations

    6

    h-index

  5. Biochemical Journal

    BJ · 5 publications · 113 citations

    5

    h-index

1–5