Concepedia

Initiation-promotion-progression Model

The Initiation-Promotion-Progression Model is a theoretical framework in carcinogenesis that delineates tumor development as a multistage process comprising irreversible genetic alterations during initiation, clonal expansion of initiated cells through epigenetic mechanisms in promotion, and malignant conversion via accumulated genetic instability in progression.

90

Publications

5.5K

Citations

328

Authors

106

Institutions

Publications per year

2017–2026

3

Variants

Multistage Carcinogenesis Model

Parents

Publications

90

Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion/progression stages of colon cancer.

Toshihiko Kawamori, R Lubet, Vernon E. Steele et al. · PubMed · 1999 · 592 citations

, , +14

Correlation of the inhibition by retinoids of tumor promoter-induced mouse epidermal ornithine decarboxylase activity and of skin tumor promotion.

Ajit Kumar Verma, B. G. Shapas, Hope M. Rice et al. · PubMed · 1979 · 357 citations

, , +12

The mRNA coding for the secreted protease transin is expressed more abundantly in malignant than in benign tumors.

L M Matrisian, G. Tim Bowden, Peter Krieg et al. · Proceedings of the National Academy of Sciences · 1986 · 260 citations · Full text

, , +17

Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin

Henry Hennings, Peter M. Blumberg, George R. Pettit et al. · Carcinogenesis · 1987 · 232 citations

, , +16

A mathematical model of breast cancer development, local treatment and recurrence

Heiko Enderling, Mark A. J. Chaplain, Alexander R.A. Anderson et al. · Journal of Theoretical Biology · 2006 · 205 citations

, , +16

1–5 of 90

Authors

328

  1. GF
    Gerhard Fürstenberger

    German Cancer Research Center, Germany

    5 publications · 587 citations

    5

    h-index

  2. YP
    Yvonne P. Dragan

    University of Wisconsin–Madison, United States

    4 publications · 140 citations

    4

    h-index

  3. TJ
    Thomas J. Slaga

    Oak Ridge National Laboratory, United States

    4 publications · 234 citations

    4

    h-index

  4. FM
    Friedrich Marks

    German Cancer Research Center, Germany

    4 publications · 332 citations

    4

    h-index

  5. PK
    Peter Krieg

    German Cancer Research Center, Germany

    3 publications · 390 citations

    3

    h-index

1–5 of 328

Institutions

106

  1. University of Wisconsin–Madison

    Madison, United States

    10 h-index

    27 publications

    1.6K citations

  2. German Cancer Research Center

    Heidelberg, Germany

    8 h-index

    34 publications

    2.8K citations

  3. The University of Texas MD Anderson Cancer Center

    Houston, United States

    7 h-index

    28 publications

    1.5K citations

  4. Nebraska Medical Center

    Omaha, United States

    4 h-index

    7 publications

    212 citations

  5. Heidelberg University

    Heidelberg, Germany

    4 h-index

    12 publications

    1.5K citations

  6. National Institutes of Health

    Bethesda, United States

    4 h-index

    10 publications

    1.3K citations

  7. Research Triangle Park Foundation

    Durham, United States

    3 h-index

    7 publications

    203 citations

  8. DKFZ-ZMBH Alliance

    Heidelberg, Germany

    3 h-index

    19 publications

    1.2K citations

1–8 of 106

Venues

  1. PubMed

    Repository · 23 publications · 2K citations

    21

    h-index

  2. Carcinogenesis

    19 publications · 1K citations

    15

    h-index

  3. Molecular Carcinogenesis

    9 publications · 579 citations

    9

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 6 publications · 498 citations

    6

    h-index

  5. Cancer

    2 publications · 108 citations

    2

    h-index

1–5