Concepedia

Initiating Mutations

Initiating Mutation is a genetic alteration that confers a selective growth advantage to a somatic cell and is both necessary and sufficient to commence the neoplastic transformation process in a previously normal tissue cell.

47

Publications

4.7K

Citations

331

Authors

120

Institutions

Publications per year

2017–2026

11

Variants

Initiating Mutation

Parents

Publications

47

DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome

Timothy J. Ley, Elaine R. Mardis, Li Ding et al. · Nature · 2008 · 1.4K citations · Full text

, , +14

OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells

Irina V. Kovtun, Yuan Liu, Magnar Bjørås et al. · Nature · 2007 · 441 citations · Full text

, , +6

Mammalian cell genetics. II. Chemical induction of specific locus mutations in Chinese hamster cells in vitro.

E.H.Y. Chu, H.V. Malling · Proceedings of the National Academy of Sciences · 1968 · 375 citations

, , +12

Fetal origins of the <i>TEL-AML1</i> fusion gene in identical twins with leukemia

Anthony M. Ford, Caroline Bennett, Cathy M. Price et al. · Proceedings of the National Academy of Sciences · 1998 · 319 citations · Full text

, , +17

Acquired Initiating Mutations in Early Hematopoietic Cells of CLL Patients

Frédérik Damm, Elena Mylonas, Adrien Cosson et al. · Cancer Discovery · 2014 · 249 citations

, , +17

1–5 of 47

Authors

331

  1. WH
    W. Heidenreich

    Federal Office for Radiation Protection, Germany

    3 publications · 80 citations

    3

    h-index

  2. BL
    Barbara L. Parsons

    National Center for Toxicological Research, United States

    2 publications · 27 citations

    2

    h-index

  3. TJ
    Timothy J. Ley

    Washington University in St. Louis, United States

    2 publications · 1.5K citations

    2

    h-index

  4. WD
    William D. Shannon

    Washington University in St. Louis, United States

    2 publications · 1.5K citations

    2

    h-index

  5. MJ
    Matthew J. Walter

    Washington University in St. Louis, United States

    2 publications · 1.5K citations

    2

    h-index

1–5 of 331

Institutions

120

  1. Memorial Sloan Kettering Cancer Center

    New York, United States

    4 h-index

    8 publications

    618 citations

  2. Oak Ridge National Laboratory

    Oak Ridge, United States

    3 h-index

    4 publications

    777 citations

  3. Washington University in St. Louis

    St Louis, United States

    3 h-index

    12 publications

    3.1K citations

  4. University of Utah

    Salt Lake City, United States

    2 h-index

    3 publications

    483 citations

  5. University of Oxford

    Oxford, United Kingdom

    2 h-index

    17 publications

    568 citations

  6. Karolinska Institutet

    Stockholm, Sweden

    2 h-index

    13 publications

    838 citations

  7. Cancer Research And Biostatistics

    Seattle, United States

    2 h-index

    2 publications

    1.5K citations

  8. National Center for Toxicological Research

    Pine Bluff, United States

    2 h-index

    7 publications

    87 citations

1–8 of 120

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 733 citations

    3

    h-index

  2. 3

    h-index

  3. Radiation Research

    3 publications · 80 citations

    3

    h-index

  4. Nature

    3 publications · 2.1K citations

    3

    h-index

  5. Cancers

    2 publications · 68 citations

    2

    h-index

1–5