Concepedia

Immunogenicity Optimization

Immunogenicity Optimization is a computational or experimental strategy, as a methodological framework, that systematically enhances the ability of vaccine antigens to elicit specific and robust immune responses by refining their molecular properties, structural features, or delivery contexts to maximize immunogenic potential while maintaining safety and specificity.

140

Publications

6.8K

Citations

915

Authors

297

Institutions

Publications per year

2017–2026

46

Parents

Publications

140

A novel method for producing anti-peptide antibodies. Production of site-specific antibodies to the T cell antigen receptor beta-chain.

David N. Posnett, Helen McGrath, James P. Tam · Journal of Biological Chemistry · 1988 · 466 citations · Full text

, , +11

Live attenuated influenza virus vaccines by computer-aided rational design

Steffen Mueller, J. Robert Coleman, Dimitris Papamichail et al. · Nature Biotechnology · 2010 · 277 citations · Full text

, , +14

Universal influenza A vaccine: Optimization of M2-based constructs

Marina De Filette, Willy Min Jou, Ashley J. Birkett et al. · Virology · 2005 · 222 citations

, , +12

A computationally optimized broadly reactive antigen (COBRA) based H5N1 VLP vaccine elicits broadly reactive antibodies in mice and ferrets

Brendan M. Giles, Ted M. Ross · Vaccine · 2011 · 205 citations

, , +16

Design and Characterization of a Computationally Optimized Broadly Reactive Hemagglutinin Vaccine for H1N1 Influenza Viruses

Donald M. Carter, Christopher A. Darby, Bradford C. Lefoley et al. · Journal of Virology · 2016 · 190 citations · Full text

, , +17

1–5 of 140

Authors

915

  1. TM
    Ted M. Ross

    University of Georgia, United States

    8 publications · 633 citations

    8

    h-index

  2. BW
    Britta Wahrén

    Karolinska Institutet, Sweden

    3 publications · 84 citations

    3

    h-index

  3. KE
    Karl E. Griswold

    Dartmouth College, United States

    3 publications · 119 citations

    3

    h-index

  4. OK
    Oliver Kohlbacher

    University of Tübingen, Germany

    3 publications · 113 citations

    3

    h-index

  5. CB
    Chris Bailey‐Kellogg

    Dartmouth College, United States

    3 publications · 119 citations

    3

    h-index

1–5 of 915

Institutions

297

  1. University of Georgia

    Athens, United States

    10 h-index

    28 publications

    1.8K citations

  2. National Institute of Allergy and Infectious Diseases

    Bethesda, United States

    6 h-index

    23 publications

    1.4K citations

  3. National Institutes of Health

    Bethesda, United States

    6 h-index

    19 publications

    1.2K citations

  4. Karolinska Institutet

    Stockholm, Sweden

    4 h-index

    16 publications

    378 citations

  5. Icahn School of Medicine at Mount Sinai

    New York, United States

    3 h-index

    5 publications

    516 citations

  6. The University of Queensland

    Brisbane, Australia

    3 h-index

    14 publications

    315 citations

  7. University of Washington

    Seattle, United States

    3 h-index

    11 publications

    603 citations

  8. Ghent University

    Ghent, Belgium

    3 h-index

    17 publications

    911 citations

1–8 of 297

Venues

  1. Vaccine

    30 publications · 1.4K citations

    20

    h-index

  2. Journal of Virology

    JVI · 8 publications · 780 citations

    8

    h-index

  3. PLoS ONE

    5 publications · 187 citations

    5

    h-index

  4. Virology

    5 publications · 432 citations

    5

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 323 citations

    3

    h-index

1–5