Concepedia

Hypoxia-mediated Stemness

Hypoxia-Mediated Stemness is a biological mechanism whereby low oxygen tension selectively promotes and maintains the undifferentiated, self-renewing, and tumor-initiating properties of cancer stem cells through hypoxia-inducible factor-dependent signaling pathways.

368

Publications

27.6K

Citations

2.5K

Authors

769

Institutions

Publications per year

2017–2026

172

Parents

Publications

368

Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m <sup>6</sup> A-demethylation of NANOG mRNA

Chuanzhao Zhang, Debangshu Samanta, Haiquan Lu et al. · Proceedings of the National Academy of Sciences · 2016 · 1K citations · Full text

, , +17

A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche

Yoon-Young Jang, Saul J. Sharkis · Blood · 2007 · 878 citations · Full text

, , +17

The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype

John M. Heddleston, Zhizhong Li, Roger E. McLendon et al. · Cell Cycle · 2009 · 785 citations · Full text

, , +17

Hypoxia Enhances the Generation of Induced Pluripotent Stem Cells

Yoshinori Yoshida, Kazutoshi Takahashi, Keisuke Okita et al. · Cell stem cell · 2009 · 764 citations · Full text

, , +12

Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia

Sarah J. Conley, Elizabeth Gheordunescu, Pramod Kakarala et al. · Proceedings of the National Academy of Sciences · 2012 · 669 citations · Full text

, , +17

1–5 of 368

Authors

2.5K

  1. PD
    Persio Dello Sbarba

    University of Florence, Italy

    10 publications · 800 citations

    10

    h-index

  2. HL
    Haiquan Lu

    Johns Hopkins University, United States

    7 publications · 1.8K citations

    7

    h-index

  3. GL
    Gregg L. Semenza

    Johns Hopkins University, United States

    7 publications · 1.8K citations

    7

    h-index

  4. PW
    Pan Wang

    Sun Yat-sen University, China

    6 publications · 296 citations

    6

    h-index

  5. ZI
    Zoran Ivanović

    Université de Bordeaux, France

    6 publications · 320 citations

    6

    h-index

1–5 of 2.5K

Institutions

769

  1. University of Florence

    Florence, Italy

    12 h-index

    42 publications

    3.4K citations

  2. Johns Hopkins University

    Baltimore, United States

    11 h-index

    70 publications

    15.9K citations

  3. Sun Yat-sen University

    Guangzhou, China

    10 h-index

    37 publications

    5.6K citations

  4. Johns Hopkins Medicine

    Baltimore, United States

    10 h-index

    68 publications

    14.1K citations

  5. University of Hong Kong

    Pok Fu Lam, Hong Kong

    9 h-index

    49 publications

    4.7K citations

  6. Huazhong University of Science and Technology

    Wuhan, China

    9 h-index

    52 publications

    1.3K citations

  7. Army Medical University

    Chongqing, China

    7 h-index

    47 publications

    2.2K citations

  8. University of Bologna

    Bologna, Italy

    7 h-index

    32 publications

    2.2K citations

1–8 of 769

Venues

  1. PLoS ONE

    15 publications · 1.1K citations

    13

    h-index

  2. Scientific Reports

    14 publications · 818 citations

    12

    h-index

  3. Blood

    11 publications · 1.8K citations

    11

    h-index

  4. Cancer Research

    11 publications · 775 citations

    11

    h-index

  5. Stem Cells

    10 publications · 837 citations

    10

    h-index

1–5