Concepedia

Hypoxia-induced Stemness

Hypoxia-Induced Stemness is a molecular oncology construct that denotes the phenomenon whereby low oxygen tension selectively activates transcriptional and epigenetic programs to enhance the self-renewal, pluripotency, and tumor-initiating capacity of cancer stem cells.

208

Publications

15.6K

Citations

1.5K

Authors

504

Institutions

Publications per year

2017–2026

104

Parents

Publications

208

Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m <sup>6</sup> A-demethylation of NANOG mRNA

Chuanzhao Zhang, Debangshu Samanta, Haiquan Lu et al. · Proceedings of the National Academy of Sciences · 2016 · 1K citations · Full text

, , +17

The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype

John M. Heddleston, Zhizhong Li, Roger E. McLendon et al. · Cell Cycle · 2009 · 785 citations · Full text

, , +17

Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia

Sarah J. Conley, Elizabeth Gheordunescu, Pramod Kakarala et al. · Proceedings of the National Academy of Sciences · 2012 · 669 citations · Full text

, , +17

Hypoxia enhances proliferation and tissue formation of human mesenchymal stem cells

Warren L. Grayson, Feng Zhao, Bruce A. Bunnell et al. · Biochemical and Biophysical Research Communications · 2007 · 525 citations

, , +14

Low oxygen tension inhibits osteogenic differentiation and enhances stemness of human MIAMI cells

Gianluca D’Ippolito, Sylma Diabira, Guy A. Howard et al. · Bone · 2006 · 381 citations

, , +15

1–5 of 208

Authors

1.5K

  1. PW
    Pan Wang

    Sun Yat-sen University, China

    5 publications · 257 citations

    5

    h-index

  2. SX
    Shuanglong Xiong

    Chongqing Cancer Hospital, China

    5 publications · 257 citations

    5

    h-index

  3. HL
    Haiquan Lu

    Johns Hopkins University, United States

    5 publications · 1.3K citations

    5

    h-index

  4. NW
    Nan Wu

    Southwest Hospital, China

    5 publications · 257 citations

    5

    h-index

  5. GL
    Gregg L. Semenza

    Johns Hopkins University, United States

    5 publications · 1.3K citations

    5

    h-index

1–5 of 1.5K

Institutions

504

  1. Johns Hopkins Medicine

    Baltimore, United States

    7 h-index

    53 publications

    11.7K citations

  2. Huazhong University of Science and Technology

    Wuhan, China

    7 h-index

    51 publications

    1.3K citations

  3. Johns Hopkins University

    Baltimore, United States

    7 h-index

    53 publications

    11.7K citations

  4. Sun Yat-sen University

    Guangzhou, China

    6 h-index

    19 publications

    3.8K citations

  5. Tongji Hospital

    Wuhan, China

    5 h-index

    28 publications

    704 citations

  6. Army Medical University

    Chongqing, China

    5 h-index

    30 publications

    1.7K citations

  7. University of Bologna

    Bologna, Italy

    5 h-index

    29 publications

    2.8K citations

  8. Centre National de la Recherche Scientifique

    Paris, France

    5 h-index

    23 publications

    724 citations

1–8 of 504

Venues

  1. Oncotarget

    10 publications · 434 citations

    10

    h-index

  2. Scientific Reports

    9 publications · 454 citations

    9

    h-index

  3. PLoS ONE

    8 publications · 550 citations

    8

    h-index

  4. Cancer Research

    8 publications · 524 citations

    8

    h-index

  5. Oncology Reports

    7 publications · 185 citations

    7

    h-index

1–5