Concepedia

Hydrolytic Bioactivation

Hydrolytic Bioactivation is a bioprecursor prodrug activation mechanism in which a pharmacologically inactive precursor undergoes enzymatic or chemical hydrolysis to release the active drug moiety, distinguished from other bioactivation pathways by its reliance on cleavage of functional groups via hydrolytic reactions.

17

Publications

828

Citations

100

Authors

34

Institutions

Publications per year

2017–2026

4

Parents

Publications

17

Inhibition of nitric oxide synthesis by N<sup>G</sup>‐nitro‐L‐arginine methyl ester (L‐NAME): requirement for bioactivation to the free acid, N<sup>G</sup>‐nitro‐L‐arginine

Silvia Pfeiffer, Eva Leopold, Kurt Schmidt et al. · British Journal of Pharmacology · 1996 · 236 citations · Full text

, , +8

Structural Basis for Clinical Longevity of Carbapenem Antibiotics in the Face of Challenge by the Common Class A β-Lactamases from the Antibiotic-Resistant Bacteria

Laurent Maveyraud, Lionel Mourey, Lakshmi P. Kotra et al. · Journal of the American Chemical Society · 1998 · 149 citations · Full text

, , +17

Catalytic detoxification of nerve agent and pesticide organophosphates by butyrylcholinesterase assisted with non-pyridinium oximes

Zoran Radić, Trevor J. Dale, Zrinka Kovarik et al. · Biochemical Journal · 2012 · 88 citations · Full text

, , +16

Enzymology of the reductive bioactivation of SR 4233

Michael I. Walton, Paul Workman · Biochemical Pharmacology · 1990 · 69 citations

, , +12

THE DESTRUCTION OF GLUCAGON, ADRENOCORTICOTROPIN AND SOMATOTROPIN BY HUMAN BLOOD PLASMA*

I. Arthur Mirsky, Gladys Perisutti, Neil C. Davis · Journal of Clinical Investigation · 1959 · 47 citations · Full text

, , +16

1–5 of 17

Authors

100

  1. TI
    Takashi Izumi

    Gunma University, Japan

    2 publications · 52 citations

    2

    h-index

  2. MB
    Michele Bassi

    Forestry Research Centre, Italy

    1 publications · 17 citations

    1

    h-index

  3. WW
    Whei‐Mei Wu

    University of Florida, United States

    1 publications · 19 citations

    1

    h-index

  4. KK
    Kazuishi Kubota

    Daiichi-Sankyo (Japan), Japan

    1 publications · 17 citations

    1

    h-index

  5. GS
    G. Somogyi

    Hungarian Academy of Sciences, Hungary

    1 publications · 19 citations

    1

    h-index

1–5 of 100

Institutions

34

  1. Daiichi-Sankyo (Japan)

    Tokyo, Japan

    2 h-index

    10 publications

    188 citations

  2. Cairo University

    Giza, Egypt

    1 h-index

    1 publications

    14 citations

  3. Shanghai Institute of Materia Medica

    Pudong, China

    1 h-index

    3 publications

    84 citations

  4. University of Debrecen

    Debrecen, Hungary

    1 h-index

    1 publications

    19 citations

  5. Bristol-Myers Squibb (United States)

    New York, United States

    1 h-index

    11 publications

    143 citations

  6. University of Toronto

    Toronto, Canada

    1 h-index

    3 publications

    60 citations

  7. Daiichi Sankyo (Germany)

    Munich, Germany

    1 h-index

    9 publications

    153 citations

  8. King Saud University

    Riyadh, Saudi Arabia

    1 h-index

    3 publications

    42 citations

1–8 of 34

Venues

  1. Drug Metabolism and Disposition

    2 publications · 52 citations

    2

    h-index

  2. Toxicology and Applied Pharmacology

    TAAP · 1 publications · 20 citations

    1

    h-index

  3. Scientific Reports

    1 publications · 17 citations

    1

    h-index

  4. Xenobiotica

    1 publications · 13 citations

    1

    h-index

  5. Journal of Medicinal Chemistry

    1 publications · 13 citations

    1

    h-index

1–5