Concepedia

Hybridization Affinity

Hybridization Affinity is a biochemical metric that quantifies the strength of binding interaction between a modified nucleic acid strand and its complementary sequence, distinguishing it from general nucleic acid interactions by its specific dependence on chemical modifications that influence duplex stability.

161

Publications

10.1K

Citations

577

Authors

177

Institutions

Publications per year

2017–2026

13

Parents

Publications

161

Evaluation of 2‘-modified oligonucleotides containing 2‘-deoxy gaps as antisense inhibitors of gene expression

Brett P. Monia, Elena A. Lesnik, C. Gonzalez et al. · Journal of Biological Chemistry · 1993 · 770 citations · Full text

, , +16

The ups and downs of nucleic acid duplex stability: structure-stability studies on chemically-modified DNA:RNA duplexes

Sandra Freier · Nucleic Acids Research · 1997 · 684 citations · Full text

, , +17

Hybridization of nucleic acids immobilized on a quartz crystal microbalance

Yoshio Okahata, Yuka Matsunobu, Kuniharu Ijiro et al. · Journal of the American Chemical Society · 1992 · 284 citations

, , +9

Predicting oligonucleotide affinity to nucleic acid targets

David H. Mathews, Mark E. Burkard, Susan M. Freier et al. · RNA · 1999 · 255 citations · Full text

, , +17

Sequences flanking the hexameric G-box core CACGTG affect the specificity of protein binding.

Mary Elizabeth Williams, Randy Foster, Nam‐Hai Chua · The Plant Cell · 1992 · 249 citations · Full text

, , +16

1–5 of 161

Authors

577

  1. JW
    Jesper Wengel

    University of Southern Denmark, Denmark

    9 publications · 445 citations

    9

    h-index

  2. CR
    Clemens Richert

    University of Stuttgart, Germany

    8 publications · 156 citations

    8

    h-index

  3. HB
    Hans Binder

    Leipzig University, Germany

    5 publications · 198 citations

    5

    h-index

  4. MS
    Mitsuo Sekine

    Tokyo Institute of Technology, Japan

    4 publications · 107 citations

    4

    h-index

  5. KS
    Kohji Seio

    Tokyo Institute of Technology, Japan

    4 publications · 107 citations

    4

    h-index

1–5 of 577

Institutions

177

  1. University of Southern Denmark

    Odense, Denmark

    9 h-index

    23 publications

    1.3K citations

  2. Ionis Pharmaceuticals (United States)

    Carlsbad, United States

    8 h-index

    33 publications

    9.6K citations

  3. Leipzig University

    Leipzig, Germany

    5 h-index

    15 publications

    564 citations

  4. Heidelberg University

    Heidelberg, Germany

    4 h-index

    15 publications

    788 citations

  5. University of Copenhagen

    Copenhagen, Denmark

    4 h-index

    7 publications

    390 citations

  6. Centre National de la Recherche Scientifique

    Paris, France

    4 h-index

    6 publications

    568 citations

  7. Karlsruhe Institute of Technology

    Karlsruhe, Germany

    4 h-index

    12 publications

    387 citations

  8. Tokyo Institute of Technology

    Tokyo, Japan

    4 h-index

    25 publications

    542 citations

1–8 of 177

Venues

  1. Journal of the American Chemical Society

    JACS · 17 publications · 1.3K citations

    16

    h-index

  2. Biochemistry

    13 publications · 867 citations

    13

    h-index

  3. Nucleic Acids Research

    11 publications · 1.3K citations

    11

    h-index

  4. Bioconjugate Chemistry

    6 publications · 189 citations

    6

    h-index

  5. The Journal of Organic Chemistry

    JOC · 5 publications · 298 citations

    5

    h-index

1–5