Concepedia

Humanized Bone Marrow Models

Humanized Bone Marrow Models is a preclinical research model that integrates human hematopoietic stem cells into immunodeficient animal hosts to reconstitute a human-like bone marrow microenvironment, enabling the in vivo study of human hematopoiesis, immune development, and related diseases within a living organism.

66

Publications

3.8K

Citations

566

Authors

183

Institutions

Publications per year

2017–2026

33

Parents

Publications

66

Parameters for establishing humanized mouse models to study human immunity: Analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rγnull mutation

Michael A. Brehm, Amy Cuthbert, Chaoxing Yang et al. · Clinical Immunology · 2010 · 265 citations

, , +17

The analysis of the functions of human B and T cells in humanized NOD/shi-scid/γcnull (NOG) mice (hu-HSC NOG mice)

Y. Watanabe, Takeshi Takahashi, Akira Okajima et al. · International Immunology · 2009 · 216 citations · Full text

, , +17

A humanized bone marrow ossicle xenotransplantation model enables improved engraftment of healthy and leukemic human hematopoietic cells

Andreas Reinisch, Danièl Thomas, M. Ryan Corces et al. · Nature Medicine · 2016 · 216 citations · Full text

, , +14

An Improved Patient-Derived Xenograft Humanized Mouse Model for Evaluation of Lung Cancer Immune Responses

Ismail M. Meraz, Mourad Majidi, Feng Meng et al. · Cancer Immunology Research · 2019 · 168 citations · Full text

, , +17

Comparison of Mesenchymal Stromal Cells From Different Origins for the Treatment of Graft-vs.-Host-Disease in a Humanized Mouse Model

Céline Grégoire, Caroline Ritacco, Muriel Hannon et al. · Frontiers in Immunology · 2019 · 139 citations · Full text

, , +15

1–5 of 66

Authors

566

  1. MG
    Markus G. Manz

    University Hospital of Zurich, Switzerland

    4 publications · 141 citations

    4

    h-index

  2. AA
    Ander Abarrategi

    The Francis Crick Institute, United Kingdom

    4 publications · 189 citations

    4

    h-index

  3. PB
    Paul Bourgine

    University Hospital of Basel, Switzerland

    4 publications · 104 citations

    4

    h-index

  4. SS
    Saki Shimizu

    Osaka University of Pharmaceutical Sciences, Japan

    4 publications · 234 citations

    4

    h-index

  5. VR
    Valerie Rezek

    University of California, Los Angeles, United States

    4 publications · 154 citations

    4

    h-index

1–5 of 566

Institutions

183

  1. University of California, Los Angeles

    Los Angeles, United States

    6 h-index

    51 publications

    2.5K citations

  2. University of Zurich

    Zurich, Switzerland

    5 h-index

    7 publications

    297 citations

  3. Black AIDS Institute

    Los Angeles, United States

    5 h-index

    35 publications

    1.9K citations

  4. Central Institute for Experimental Animals

    Kawasaki, Japan

    5 h-index

    16 publications

    1.1K citations

  5. Fred Hutch Cancer Center

    Seattle, United States

    4 h-index

    7 publications

    384 citations

  6. University Hospital of Zurich

    Zurich, Switzerland

    4 h-index

    6 publications

    187 citations

  7. The Francis Crick Institute

    London, United Kingdom

    4 h-index

    25 publications

    1.2K citations

  8. Yale University

    New Haven, United States

    3 h-index

    60 publications

    2.8K citations

1–8 of 183

Venues

  1. PLoS ONE

    7 publications · 321 citations

    7

    h-index

  2. Frontiers in Immunology

    4 publications · 261 citations

    4

    h-index

  3. Journal of Virology

    JVI · 3 publications · 259 citations

    3

    h-index

  4. Journal of Visualized Experiments

    3 publications · 57 citations

    3

    h-index

  5. Nature Protocols

    2 publications · 199 citations

    2

    h-index

1–5