Concepedia

Humanized Antibodies

Humanized Antibodies is a type of recombinant monoclonal antibody in which the complementarity-determining regions (CDRs) from a non-human antibody are grafted onto a human antibody framework to reduce immunogenicity while preserving antigen specificity.

406

Publications

35.1K

Citations

2.9K

Authors

763

Institutions

Publications per year

2017–2026

100

Parents

Publications

406

Tuberculosis Associated with Infliximab, a Tumor Necrosis Factor α–Neutralizing Agent

Joseph Keane, Sharon K. Gershon, Robert P. Wise et al. · New England Journal of Medicine · 2001 · 3.7K citations · Full text

, , +16

Reshaping human antibodies for therapy

Lutz Riechmann, Herman Waldmann, Greg Winter · Nature · 1988 · 1.6K citations

, , +12

Replacing the complementarity-determining regions in a human antibody with those from a mouse

Peter Jones, Paul H. Dear, Jefferson Foote et al. · Nature · 1986 · 1.4K citations

, , +13

Humanized anti–interleukin-6 receptor antibody treatment of multicentric Castleman disease

Norihiro Nishimoto, Yuzuru Kanakura, Katsuyuki Aozasa et al. · Blood · 2005 · 750 citations · Full text

, , +12

The immunogenicity of humanized and fully human antibodies

Fiona Harding, Marcia Stickler, Jennifer Razo et al. · mAbs · 2010 · 727 citations · Full text

, , +17

1–5 of 406

Authors

2.9K

  1. HW
    Herman Waldmann

    University of Oxford, United Kingdom

    7 publications · 2.2K citations

    7

    h-index

  2. CQ
    Cary Queen

    PDL BioPharma (United States), United States

    7 publications · 1.1K citations

    7

    h-index

  3. GH
    G Hale

    University of Cambridge, United Kingdom

    6 publications · 661 citations

    6

    h-index

  4. MM
    Mary M. Bendig

    LifeArc, United Kingdom

    6 publications · 516 citations

    6

    h-index

  5. SV
    S. V. S. Kashmiri

    National Cancer Institute, United States

    5 publications · 242 citations

    5

    h-index

1–5 of 2.9K

Institutions

763

  1. PDL BioPharma (United States)

    Incline Village, United States

    15 h-index

    86 publications

    21K citations

  2. National Institutes of Health

    Bethesda, United States

    13 h-index

    36 publications

    2K citations

  3. National Cancer Institute

    Bethesda, United States

    10 h-index

    25 publications

    1.3K citations

  4. Biogen (United States)

    Cambridge, United States

    9 h-index

    57 publications

    6.7K citations

  5. University of Cambridge

    Cambridge, United Kingdom

    9 h-index

    29 publications

    3.3K citations

  6. Eli Lilly (United States)

    Indianapolis, United States

    9 h-index

    43 publications

    2.5K citations

  7. Merck & Co., Inc., Rahway, NJ, USA (United States)

    Rahway, United States

    8 h-index

    33 publications

    2.4K citations

  8. The University of Texas MD Anderson Cancer Center

    Houston, United States

    7 h-index

    16 publications

    1.7K citations

1–8 of 763

Venues

  1. PubMed

    Repository · 25 publications · 1.1K citations

    17

    h-index

  2. mAbs

    19 publications · 2K citations

    17

    h-index

  3. The Journal of Immunology

    JI · 15 publications · 971 citations

    14

    h-index

  4. Journal of Clinical Oncology

    15 publications · 1.4K citations

    12

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 10 publications · 1.3K citations

    10

    h-index

1–5