Concepedia

Hrs Complex

The Hrs Complex is a protein complex within the endosomal sorting machinery that selectively recognizes ubiquitinated cargo and mediates their sequestration into intraluminal vesicles of multivesicular bodies through its phosphoinositide-binding and clathrin-interacting domains.

44

Publications

5K

Citations

218

Authors

96

Institutions

Publications per year

2017–2026

9

Variants

Escrt-0Escrt-0 Complex

Parents

Publications

44

Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes

Camilla Raiborg, Kristi G. Bache, David J. Gillooly et al. · Nature Cell Biology · 2002 · 715 citations

, , +16

Hrs Regulates Endosome Membrane Invagination and Tyrosine Kinase Receptor Signaling in Drosophila

Thomas E. Lloyd, Richard Atkinson, Mark N. Wu et al. · Cell · 2002 · 432 citations · Full text

, , +14

Retrotranslocation of a Misfolded Luminal ER Protein by the Ubiquitin-Ligase Hrd1p

Pedro Carvalho, Ann Marie Stanley, Tom A. Rapoport · Cell · 2010 · 301 citations · Full text

, , +14

Structural basis of ER-associated protein degradation mediated by the Hrd1 ubiquitin ligase complex

Xudong Wu, Marc Siggel, Sergey Ovchinnikov et al. · Science · 2020 · 244 citations · Full text

, , +17

Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis

Masayuki Komada, Philippe Soriano · Genes & Development · 1999 · 234 citations · Full text

, , +12

1–5 of 44

Authors

218

  1. TA
    Tom A. Rapoport

    Harvard University, United States

    4 publications · 775 citations

    4

    h-index

  2. AJ
    Andrew J. Bean

    The University of Texas Health Science Center at Houston, United States

    3 publications · 186 citations

    3

    h-index

  3. CR
    Camilla Raiborg

    University of Oslo, Norway

    2 publications · 887 citations

    2

    h-index

  4. NK
    Naomi Kitamura

    Tokyo Institute of Technology, Japan

    2 publications · 263 citations

    2

    h-index

  5. MK
    Masaki Kato

    Chiba University, Japan

    2 publications · 263 citations

    2

    h-index

1–5 of 218

Institutions

96

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    7 h-index

    19 publications

    4.2K citations

  2. Harvard University

    Cambridge, United States

    4 h-index

    12 publications

    2.6K citations

  3. National Institutes of Health

    Bethesda, United States

    2 h-index

    3 publications

    94 citations

  4. University of Maryland, Baltimore

    Baltimore, United States

    2 h-index

    7 publications

    274 citations

  5. The University of Texas Health Science Center at Houston

    Houston, United States

    2 h-index

    10 publications

    564 citations

  6. University of Wisconsin–Madison

    Madison, United States

    2 h-index

    4 publications

    342 citations

  7. Centre National de la Recherche Scientifique

    Paris, France

    2 h-index

    8 publications

    236 citations

  8. Tokyo Institute of Technology

    Tokyo, Japan

    2 h-index

    9 publications

    900 citations

1–8 of 96

Venues

  1. Journal of Biological Chemistry

    JBC · 8 publications · 897 citations

    8

    h-index

  2. Cell

    4 publications · 1.1K citations

    4

    h-index

  3. Molecular Biology of the Cell

    MBC · 4 publications · 208 citations

    4

    h-index

  4. Nature Cell Biology

    NCB · 3 publications · 834 citations

    3

    h-index

  5. Biochemical and Biophysical Research Communications

    BBRC · 2 publications · 183 citations

    2

    h-index

1–5