Concepedia

Hexosamine Biosynthesis Pathway

The Hexosamine Biosynthesis Pathway is a metabolic pathway that diverts a small fraction of glucose flux through the uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) synthesis route, serving as a nutrient sensor and regulator of post-translational modifications via O-GlcNAcylation in cancer cells.

541

Publications

39.3K

Citations

2.8K

Authors

775

Institutions

Publications per year

2017–2026

149

Variants

Hbp

Parents

Publications

541

Biochemical and Metabolic Abnormalities in Articular Cartilage from Osteo-Arthritic Human Hips

Henry J. Mankin, HOWARD DORFMAN, Louis Lippiello et al. · Journal of Bone and Joint Surgery · 1971 · 2K citations

, , +17

Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation

Xue-Liang Du, Diane Edelstein, Luciano Rossetti et al. · Proceedings of the National Academy of Sciences · 2000 · 1.1K citations

, , +17

Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance.

Stephen Marshall, V. Bacote, R.R. Traxinger · Journal of Biological Chemistry · 1991 · 1K citations · Full text

, , +17

Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site

Xue Du, Diane Edelstein, Stefanie Dimmeler et al. · Journal of Clinical Investigation · 2001 · 883 citations

, , +14

Biochemical and Metabolic Abnormalities in Articular Cartilage from Osteo-Arthritic Human Hips

Henry J. Mankin, Louis Lippiello · Journal of Bone and Joint Surgery · 1970 · 852 citations

, , +17

1–5 of 541

Authors

2.8K

  1. DA
    Donald A. McClain

    University of Utah, United States

    24 publications · 2.3K citations

    21

    h-index

  2. ED
    Errol D. Crook

    University of Mississippi Medical Center, United States

    13 publications · 910 citations

    13

    h-index

  3. JC
    John C. Chatham

    University of Alabama at Birmingham, United States

    12 publications · 1K citations

    12

    h-index

  4. MG
    Maria G. Buse

    Medical University of South Carolina, United States

    11 publications · 949 citations

    11

    h-index

  5. JA
    John A. Hanover

    National Institutes of Health, United States

    10 publications · 1.6K citations

    10

    h-index

1–5 of 2.8K

Institutions

775

  1. University of Alabama at Birmingham

    Birmingham, United States

    18 h-index

    80 publications

    6.1K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    18 h-index

    125 publications

    9.5K citations

  3. University of Utah

    Salt Lake City, United States

    16 h-index

    59 publications

    6.8K citations

  4. Inserm

    Paris, France

    14 h-index

    100 publications

    8.2K citations

  5. Johns Hopkins University

    Baltimore, United States

    13 h-index

    43 publications

    4.3K citations

  6. University of Mississippi Medical Center

    Jackson, United States

    13 h-index

    42 publications

    4.1K citations

  7. University of Toronto

    Toronto, Canada

    12 h-index

    31 publications

    3.5K citations

  8. Albert Einstein College of Medicine

    Bronx, United States

    11 h-index

    59 publications

    15.9K citations

1–8 of 775

Venues

  1. Journal of Biological Chemistry

    JBC · 52 publications · 5.8K citations

    41

    h-index

  2. Diabetes

    30 publications · 2.4K citations

    27

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 16 publications · 4.1K citations

    16

    h-index

  4. Journal of Clinical Investigation

    JCI · 13 publications · 3.2K citations

    13

    h-index

  5. 13

    h-index

1–5