Concepedia

Hepatocyte Uptake

Hepatocyte Uptake is the process by which hepatocytes, the primary functional cells of the liver, actively internalize substances from the portal circulation, distinguished by its role in the initial sequestration of xenobiotics and endogenous compounds prior to metabolic transformation in first-pass hepatic extraction.

976

Publications

48.5K

Citations

3.5K

Authors

821

Institutions

Publications per year

2017–2026

57

Parents

Publications

976

Hepatitis B and D Viruses Exploit Sodium Taurocholate Co-transporting Polypeptide for Species-Specific Entry into Hepatocytes

Yi Ni, Florian A. Lempp, Stefan Mehrle et al. · Gastroenterology · 2013 · 766 citations · Full text

, , +11

The galactose-specific recognition system of mammalian liver: The route of ligand internalization in rat hepatocytes

Doris A. Wall, Glynn Wilson, Ann L. Hubbard · Cell · 1980 · 483 citations

, , +9

Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the Hepatic Uptake of Pitavastatin in Humans

Masaru Hirano, Kazuya Maeda, Yoshihisa Shitara et al. · Journal of Pharmacology and Experimental Therapeutics · 2004 · 442 citations

, , +16

Characteristics of an amino acid transport system in rat liver for glutamine, asparagine, histidine, and closely related analogs.

Michael S. Kilberg, Mary E. Handlogten, H N Christensen · Journal of Biological Chemistry · 1980 · 429 citations · Full text

, , +12

Rapid hepatic clearance of the canine lipoproteins containing only the E apoprotein by a high affinity receptor. Identity with the chylomicron remnant transport process.

Bette C. Sherrill, T L Innerarity, Robert W. Mahley · Journal of Biological Chemistry · 1980 · 425 citations · Full text

, , +17

1–5 of 976

Authors

3.5K

  1. YS
    Yuichi Sugiyama

    The University of Tokyo, Japan

    21 publications · 2.1K citations

    17

    h-index

  2. EP
    Ernst Petzinger

    Justus-Liebig-Universität Gießen, Germany

    17 publications · 522 citations

    15

    h-index

  3. AW
    Allan W. Wolkoff

    Albert Einstein College of Medicine, United States

    12 publications · 474 citations

    12

    h-index

  4. MF
    M. Frimmer

    Justus-Liebig-Universität Gießen, Germany

    13 publications · 411 citations

    12

    h-index

  5. DK
    Dirk K. F. Meijer

    University of Groningen, Netherlands

    14 publications · 501 citations

    12

    h-index

1–5 of 3.5K

Institutions

821

  1. Albert Einstein College of Medicine

    Bronx, United States

    23 h-index

    92 publications

    6.7K citations

  2. Inserm

    Paris, France

    19 h-index

    103 publications

    3.4K citations

  3. University of California, San Francisco

    San Francisco, United States

    18 h-index

    77 publications

    5.8K citations

  4. The University of Tokyo

    Tokyo, Japan

    18 h-index

    85 publications

    4.4K citations

  5. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    16 h-index

    55 publications

    3.2K citations

  6. University of Groningen

    Groningen, The Netherlands

    16 h-index

    84 publications

    3.4K citations

  7. Justus-Liebig-Universität Gießen

    Giessen, Germany

    15 h-index

    54 publications

    1.7K citations

  8. University of Oslo

    Oslo, Norway

    14 h-index

    39 publications

    2.4K citations

1–8 of 821

Venues

  1. Journal of Biological Chemistry

    JBC · 37 publications · 3.8K citations

    30

    h-index

  2. Hepatology

    44 publications · 2.3K citations

    28

    h-index

  3. PubMed

    Repository · 63 publications · 2.2K citations

    26

    h-index

  4. Drug Metabolism and Disposition

    39 publications · 2.2K citations

    26

    h-index

  5. 21

    h-index

1–5