Concepedia

Genetic Modifier Screening

Genetic Modifier Screening is a phenotypic screening strategy that identifies genetic variants capable of altering the expression or severity of a specific phenotype, thereby distinguishing itself from other screening approaches by focusing on modifier genes that influence the phenotypic outcomes of primary mutations.

34

Publications

1.6K

Citations

233

Authors

82

Institutions

Publications per year

2017–2026

12

Variants

Genetic Modifier Screens

Parents

Publications

34

A Library of Spirooxindoles Based on a Stereoselective Three-Component Coupling Reaction

Michael M.‐C. Lo, Christopher S. Neumann, Satoshi Nagayama et al. · Journal of the American Chemical Society · 2004 · 273 citations

, , +15

Heparan sulfate proteoglycan-dependent induction of axon branching and axon misrouting by the Kallmann syndrome gene <i>kal-1</i>

Hannes E. Bülow, Katherine L. Berry, Liat H. Topper et al. · Proceedings of the National Academy of Sciences · 2002 · 164 citations · Full text

, , +13

Genetic screening of LCA in Belgium: predominance of CEP290 and identification of potential modifier alleles in AHI1 of CEP290-related phenotypes

Frauke Coppieters, Ingele Casteels, Françoise Meire et al. · Human Mutation · 2010 · 146 citations · Full text

, , +14

Chemical Genetic Modifier Screens

Kathryn M. Koeller, Stephen J. Haggarty, Brian D. Perkins et al. · Chemistry & Biology · 2003 · 90 citations · Full text

, , +8

Diagnosis, prevalence, and screening of familial dilated cardiomyopathy

Mary Sweet, Matthew R.G. Taylor, Luisa Mestroni · Expert Opinion on Orphan Drugs · 2015 · 79 citations · Full text

, , +16

1–5 of 34

Authors

233

  1. SL
    Stuart L. Schreiber

    Harvard University, United States

    2 publications · 363 citations

    2

    h-index

  2. RC
    Robert C. Cumming

    Salk Institute for Biological Studies, United States

    2 publications · 104 citations

    2

    h-index

  3. BP
    Bart P. Leroy

    Ghent University Hospital, Belgium

    2 publications · 178 citations

    2

    h-index

  4. AS
    Anne Simonsen

    University of Oslo, Norway

    2 publications · 104 citations

    2

    h-index

  5. KD
    Kim D. Finley

    San Diego State University, United States

    2 publications · 104 citations

    2

    h-index

1–5 of 233

Institutions

82

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    4 h-index

    11 publications

    1.7K citations

  2. Harvard University

    Cambridge, United States

    3 h-index

    18 publications

    2.1K citations

  3. Mayo Clinic in Arizona

    Scottsdale, United States

    2 h-index

    5 publications

    123 citations

  4. Yale University

    New Haven, United States

    2 h-index

    12 publications

    298 citations

  5. Ghent University Hospital

    Ghent, Belgium

    2 h-index

    11 publications

    1.4K citations

  6. KU Leuven

    Leuven, Belgium

    2 h-index

    10 publications

    420 citations

  7. University of Michigan

    Ann Arbor, United States

    2 h-index

    4 publications

    71 citations

  8. Salk Institute for Biological Studies

    La Jolla, United States

    2 h-index

    7 publications

    409 citations

1–8 of 82

Venues

  1. Genetics

    8 publications · 291 citations

    8

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 194 citations

    3

    h-index

  3. G3 Genes Genomes Genetics

    2 publications · 32 citations

    2

    h-index

  4. Human Mutation

    2 publications · 168 citations

    2

    h-index

  5. Molecular Brain

    1 publications · 21 citations

    1

    h-index

1–5