Concepedia

Gene Knockout Simulation

Gene Knockout Simulation is a computational method in systems biology that systematically removes or inactivates specific gene-associated reactions from a metabolic model to predict the phenotypic consequences of genetic deletions on metabolic flux distributions and organismal growth.

20

Publications

1.7K

Citations

95

Authors

48

Institutions

Publications per year

2017–2026

8

Parents

Publications

20

Metabolic engineering of <i>Escherichia coli</i> for the production of <scp>l</scp> -valine based on transcriptome analysis and <i>in silico</i> gene knockout simulation

Jin Hwan Park, Kwang Ho Lee, Tae Yong Kim et al. · Proceedings of the National Academy of Sciences · 2007 · 606 citations

, , +17

<i>In Silico</i> Identification of Gene Amplification Targets for Improvement of Lycopene Production

Hyung Seok Choi, Sang Yup Lee, Tae Yong Kim et al. · Applied and Environmental Microbiology · 2010 · 299 citations

, , +16

Large-Scale Evaluation of <i>In Silico</i> Gene Deletions in <i>Saccharomyces cerevisiae</i>

Jochen Förster, Iman Famili, Bernhard Ø. Palsson et al. · OMICS A Journal of Integrative Biology · 2003 · 141 citations

, , +14

Probing the performance limits of the <i>Escherichia coli</i> metabolic network subject to gene additions or deletions

Anthony P. Burgard, Costas D. Maranas · Biotechnology and Bioengineering · 2001 · 106 citations · Full text

, , +15

Modeling and simulation of the main metabolism in Escherichia coli and its several single-gene knockout mutants with experimental verification

Tuty Asmawaty Abdul Kadir, Ahmad A. Mannan, Andrzej Kierzek et al. · Microbial Cell Factories · 2010 · 80 citations · Full text

, , +16

1–5 of 20

Authors

95

  1. TY
    Tae Yong Kim

    University of Ulsan, South Korea

    4 publications · 1K citations

    4

    h-index

  2. SY
    Sang Yup Lee

    Korea Advanced Institute of Science and Technology, South Korea

    4 publications · 1K citations

    4

    h-index

  3. MH
    Manu Harju

    Tampere University, Finland

    1 publications · 19 citations

    1

    h-index

  4. DS
    Desmond S. Lun

    Rutgers, The State University of New Jersey, United States

    1 publications · 11 citations

    1

    h-index

  5. HA
    Henrikki Almusa

    Institute for Molecular Medicine Finland, Finland

    1 publications · 19 citations

    1

    h-index

1–5 of 95

Institutions

48

  1. Korea Advanced Institute of Science and Technology

    Daejeon, South Korea

    4 h-index

    16 publications

    3K citations

  2. Intelligent Synthetic Biology Center

    Daejeon, South Korea

    3 h-index

    13 publications

    1.8K citations

  3. Science for Life Laboratory

    Stockholm, Sweden

    1 h-index

    4 publications

    152 citations

  4. Rutgers, The State University of New Jersey

    New Brunswick, United States

    1 h-index

    7 publications

    77 citations

  5. National Taiwan University

    Taipei, Taiwan

    1 h-index

    1 publications

    38 citations

  6. KTH Royal Institute of Technology

    Stockholm, Sweden

    1 h-index

    4 publications

    152 citations

  7. Keio University

    Tokyo, Japan

    1 h-index

    1 publications

    80 citations

  8. Quadram Institute

    Norwich, United Kingdom

    1 h-index

    1 publications

    19 citations

1–8 of 48

Venues

  1. Biotechnology and Bioengineering

    2 publications · 124 citations

    2

    h-index

  2. Bioinformatics

    2 publications · 35 citations

    2

    h-index

  3. OMICS A Journal of Integrative Biology

    2 publications · 156 citations

    2

    h-index

  4. Microbial Cell Factories

    2 publications · 110 citations

    2

    h-index

  5. BMC Systems Biology

    2 publications · 115 citations

    2

    h-index

1–5