Concepedia

Gc Content Optimization

GC Content Optimization is a methodological contribution in guide RNA design that refers to the systematic adjustment of guanine-cytosine base pair proportions within a guide RNA sequence to enhance thermodynamic stability and target-binding specificity.

26

Publications

1.2K

Citations

131

Authors

60

Institutions

Publications per year

2017–2026

9

Parents

Publications

26

Genomic GC level, optimal growth temperature, and genome size in prokaryotes

Héctor Musto, Hugo Naya, Alejandro Zavala et al. · Biochemical and Biophysical Research Communications · 2006 · 152 citations

, , +16

Optimization of Self-complementary AAV Vectors for Liver-directed Expression Results in Sustained Correction of Hemophilia B at Low Vector Dose

Zhijian Wu, Junjiang Sun, Taiping Zhang et al. · Molecular Therapy · 2007 · 151 citations · Full text

, , +17

Comparative Analysis of GC Content Variations in Plant Genomes

Ratnesh Singh, Ray Ming, Qingyi Yu · Tropical Plant Biology · 2016 · 91 citations

, , +11

Efficiency Optimization of CRISPR/Cas9-Mediated Targeted Mutagenesis in Grape

Fengrui Ren, Chong Ren, Zhan Zhang et al. · Frontiers in Plant Science · 2019 · 78 citations · Full text

, , +13

Identification and prevention of a GC content bias in SAGE libraries

Elliott H. Margulies · Nucleic Acids Research · 2001 · 72 citations · Full text

, , +15

1–5 of 26

Authors

131

  1. HN
    Hugo Naya

    Institut Pasteur de Montevideo, Uruguay

    2 publications · 166 citations

    2

    h-index

  2. HM
    Héctor Musto

    Centro Uruguayo de Imagenología Molecular, Uruguay

    2 publications · 166 citations

    2

    h-index

  3. AZ
    Alejandro Zavala

    Centro Uruguayo de Imagenología Molecular, Uruguay

    2 publications · 166 citations

    2

    h-index

  4. HR
    Héctor Romero

    Centro Uruguayo de Imagenología Molecular, Uruguay

    2 publications · 166 citations

    2

    h-index

  5. SP
    Sonja Pavlović

    University of Belgrade, Serbia

    1 publications · 49 citations

    1

    h-index

1–5 of 131

Institutions

60

  1. Centro Uruguayo de Imagenología Molecular

    Montevideo, Uruguay

    2 h-index

    10 publications

    692 citations

  2. Hirosaki University

    Hirosaki, Japan

    2 h-index

    2 publications

    53 citations

  3. The University of Tokyo

    Tokyo, Japan

    2 h-index

    4 publications

    106 citations

  4. Stazione Zoologica Anton Dohrn

    Naples, Italy

    2 h-index

    5 publications

    622 citations

  5. Unité mixte de recherche Œnologie

    Villenave-d'Ornon, France

    1 h-index

    1 publications

    78 citations

  6. Universidad de Extremadura

    Badajoz, Spain

    1 h-index

    3 publications

    48 citations

  7. Texas A&M University

    College Station, United States

    1 h-index

    1 publications

    91 citations

  8. École Nationale Supérieure des Sciences Agronomiques de Bordeaux-Aquitaine

    Gradignan, France

    1 h-index

    1 publications

    78 citations

1–8 of 60

Venues

  1. Nucleic Acids Research

    2 publications · 131 citations

    2

    h-index

  2. PLoS ONE

    2 publications · 62 citations

    2

    h-index

  3. Genome

    2 publications · 80 citations

    2

    h-index

  4. DNA

    1 publications · 21 citations

    1

    h-index

  5. Molecular Therapy

    1 publications · 151 citations

    1

    h-index

1–5