Concepedia

Gain-of-function Models

Gain-Of-Function Models is a transgenic organism-based experimental system in which a novel or enhanced biological function is introduced or activated through targeted genetic modification to elucidate gene function or disease mechanisms.

271

Publications

21.4K

Citations

2K

Authors

623

Institutions

Publications per year

2017–2026

80

Parents

Publications

271

A Neuroligin-3 Mutation Implicated in Autism Increases Inhibitory Synaptic Transmission in Mice

Katsuhiko Tabuchi, Jacqueline Blundell, Mark R. Etherton et al. · Science · 2007 · 1K citations

, , +17

Disruption of Splicing Regulated by a CUG-Binding Protein in Myotonic Dystrophy

Anne V. Philips, Lubov Timchenko, Thomas A. Cooper · Science · 1998 · 818 citations

, , +17

<i>Gli2</i>, but not<i>Gli1</i>, is required for initial Shh signaling and ectopic activation of the Shh pathway

Wojtek Auerbach, Joon S. Lee, Daniel Stephen et al. · Development · 2002 · 702 citations

, , +16

The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer.

Masatoshi Nakajima, Howard G. Hutchinson, Masahiko Fujinaga et al. · Proceedings of the National Academy of Sciences · 1995 · 679 citations

, , +17

<i>SCREAM/ICE1</i> and <i>SCREAM2</i> Specify Three Cell-State Transitional Steps Leading to <i>Arabidopsis</i> Stomatal Differentiation  

Masahiro M. Kanaoka, Lynn Jo Pillitteri, Hiroaki Fujii et al. · The Plant Cell · 2008 · 568 citations · Full text

, , +14

1–5 of 271

Authors

2K

  1. AL
    Alexandra L. Joyner

    New York University, United States

    3 publications · 1.1K citations

    3

    h-index

  2. SK
    Samuel K. Campos

    University of Arizona, United States

    2 publications · 30 citations

    2

    h-index

  3. DC
    David C. Bloom

    University of Florida, United States

    2 publications · 30 citations

    2

    h-index

  4. JM
    John M. Coffin

    Tufts University, United States

    2 publications · 30 citations

    2

    h-index

  5. SB
    Steeve Boulant

    Heidelberg University, Germany

    2 publications · 30 citations

    2

    h-index

1–5 of 2K

Institutions

623

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    14 h-index

    37 publications

    10.1K citations

  2. Harvard University

    Cambridge, United States

    13 h-index

    40 publications

    2.8K citations

  3. University of California San Diego

    San Diego, United States

    10 h-index

    31 publications

    2.4K citations

  4. University of Michigan

    Ann Arbor, United States

    9 h-index

    38 publications

    1.8K citations

  5. Baylor College of Medicine

    Houston, United States

    9 h-index

    39 publications

    5.6K citations

  6. Inserm

    Paris, France

    8 h-index

    34 publications

    2.9K citations

  7. University of Toronto

    Toronto, Canada

    8 h-index

    20 publications

    1.8K citations

  8. Centre National de la Recherche Scientifique

    Paris, France

    8 h-index

    23 publications

    1.9K citations

1–8 of 623

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 18 publications · 2.8K citations

    18

    h-index

  2. Development

    15 publications · 2.2K citations

    15

    h-index

  3. Journal of Neuroscience

    10 publications · 885 citations

    10

    h-index

  4. Genetics

    9 publications · 495 citations

    9

    h-index

  5. PLoS ONE

    8 publications · 438 citations

    8

    h-index

1–5