Proceedings of the National Academy of Sciences · 1995 · 679 citations · 29 references
Life SciencesDevelopmental BiologyMolecular BiologyCell SignalingGene ExpressionSignal TransductionAngiogenesisCardiovascular DevelopmentCardiovascular Molecular PhysiologyReceptor RegulationVascular DevelopmentVascular RegenerationAngiogenic ModulationAngiotensin Receptor SignalingAtherosclerosis Molecular MechanismsGain-of-function EffectsGain-of-function ModelsMitogen-activated Protein Kinase CascadesMitogen-activated Protein Kinase ModulationVascular Smooth Muscle Regulation
The type 1 angiotensin II (AT1) receptor is well characterized but the type 2 (AT2) receptor remains an enigma. We tested the hypothesis that the AT2 receptor can modulate the growth of vascular smooth muscle cells by transfecting an AT2 receptor expression vector into the balloon-injured rat carotid artery and observed that overexpression of the AT2 receptor attenuated neointimal formation. In cultured smooth muscle cells, AT2 receptor transfection reduced proliferation and inhibited mitogen-activated protein kinase activity. Furthermore, we demonstrated that the AT2 receptor mediated the developmentally regulated decrease in aortic DNA synthesis at the latter stages of gestation. These results suggest that the AT2 receptor exerts an antiproliferative effect, counteracting the growth action of AT1 receptor.
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Inhibitors of Angiotensin-Converting Enzyme Prevent Myointimal Proliferation After Vascular Injury
Jerry S. Powell, Jean-Paul Clozel, Rita Müller et al. · Science · 1989 · 1.1K citations
Medicine, Cardiology, Pharmacology +10