Concepedia

Fragment-based Repurposing

Fragment-Based Repurposing is a structure-based drug discovery approach that identifies small molecular fragments binding to a target protein and leverages their structural information to repurpose existing compounds or design new therapeutics through fragment expansion or linking.

17

Publications

768

Citations

98

Authors

43

Institutions

Publications per year

2017–2026

7

Parents

Publications

17

Drug Repurposing: An Effective Tool in Modern Drug Discovery

V. S. Kulkarni, V. Alagarsamy, V. Raja Solomon et al. · Russian Journal of Bioorganic Chemistry · 2023 · 232 citations · Full text

, , +16

A Fragment-Based Method to Discover Irreversible Covalent Inhibitors of Cysteine Proteases

Stefan G. Kathman, Ziyang Xu, Alexander V. Statsyuk · Journal of Medicinal Chemistry · 2014 · 179 citations · Full text

, , +17

Fragment-based approach for the in silico discovery of multi-target insecticides

Alejandro Speck‐Planche, Valeria V. Kleandrova, Marcus Tullius Scotti · Chemometrics and Intelligent Laboratory Systems · 2011 · 57 citations

, , +16

Identify drug repurposing candidates by mining the Protein Data Bank

Fabrice Moriaud, Stéphane Richard, Stewart A. Adcock et al. · Briefings in Bioinformatics · 2011 · 53 citations · Full text

, , +15

A fragment-based approach for efficiently creating dynamic web content

Jim Challenger, Paul Dantzig, Arun Iyengar et al. · ACM Transactions on Internet Technology · 2005 · 34 citations

, , +12

1–5 of 17

Authors

98

  1. CM
    Christopher M. McBride

    Takeda (United States), United States

    2 publications · 40 citations

    2

    h-index

  2. MT
    Mingnam Tang

    Takeda (United States), United States

    2 publications · 40 citations

    2

    h-index

  3. JD
    J. David Lawson

    Takeda (United States), United States

    2 publications · 40 citations

    2

    h-index

  4. CH
    Corine Holub

    Takeda (United States), United States

    2 publications · 40 citations

    2

    h-index

  5. PF
    Pamela Farrell

    Takeda (United States), United States

    2 publications · 40 citations

    2

    h-index

1–5 of 98

Institutions

43

  1. Takeda (United States)

    Deerfield, United States

    2 h-index

    28 publications

    544 citations

  2. VIB-VUB Center for Structural Biology

    Brussels, Belgium

    1 h-index

    1 publications

    15 citations

  3. Universidad de Oriente

    Santiago de Cuba, Cuba

    1 h-index

    1 publications

    57 citations

  4. Centre Hospitalier Universitaire de Lille

    Lille, France

    1 h-index

    3 publications

    45 citations

  5. Center for Infection and Immunity of Lille

    Lille, France

    1 h-index

    3 publications

    45 citations

  6. Université Libre de Bruxelles

    Brussels, Belgium

    1 h-index

    2 publications

    30 citations

  7. Vlaams Instituut voor Biotechnologie

    Ghent, Belgium

    1 h-index

    1 publications

    15 citations

  8. Birla Institute of Technology and Science, Pilani

    Pilāni, India

    1 h-index

    1 publications

    232 citations

1–8 of 43

Venues

  1. Journal of Medicinal Chemistry

    2 publications · 197 citations

    2

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    2 publications · 40 citations

    2

    h-index

  3. Methods in enzymology on CD-ROM/Methods in enzymology

    Book series · 1 publications · 18 citations

    1

    h-index

  4. Trends in Chemistry

    1 publications · 12 citations

    1

    h-index

  5. European Journal of Medicinal Chemistry

    1 publications · 15 citations

    1

    h-index

1–5