Concepedia

Fragment Antigen-binding Constructs

Fragment Antigen-Binding Constructs is a recombinant antibody fragment representing the smallest antigen-binding unit of an immunoglobulin, consisting of a paired heavy and light chain variable domain linked by a flexible peptide, thereby retaining specificity for target antigen binding while lacking the constant regions of a full antibody.

28

Publications

1.2K

Citations

263

Authors

74

Institutions

Publications per year

2017–2026

15

Variants

FabFab Fragments

Parents

Publications

28

Single chain Fab (scFab) fragment

Michael Hust, Thomas Jostock, Christian Menzel et al. · BMC Biotechnology · 2007 · 135 citations · Full text

, , +13

Mono‐ and Bivalent Antibody Fragments Produced in <i>Escherichia coli</i>: Engineering, Folding and Antigen Binding

Andreas Plückthun · Immunological Reviews · 1992 · 133 citations

, , +14

A Proprotein Convertase Subtilisin-like/Kexin Type 9 (PCSK9) C-terminal Domain Antibody Antigen-binding Fragment Inhibits PCSK9 Internalization and Restores Low Density Lipoprotein Uptake

Ni Yan, Jon H. Condra, Laura Orsatti et al. · Journal of Biological Chemistry · 2010 · 108 citations · Full text

, , +17

Tribody [(HER2)2xCD16] Is More Effective Than Trastuzumab in Enhancing γδ T Cell and Natural Killer Cell Cytotoxicity Against HER2-Expressing Cancer Cells

Hans‐Heinrich Oberg, Christian Kellner, Daniel Gonnermann et al. · Frontiers in Immunology · 2018 · 99 citations · Full text

, , +17

Bypassing immunization: optimized design of "designer T cells" against carcinoembryonic antigen (CEA)-expressing tumors, and lack of suppression by soluble CEA.

Kathleen F. Nolan, Yoshiko Akamatsu, J. C. Murphy et al. · PubMed · 1999 · 98 citations

, , +17

1–5 of 28

Authors

263

  1. MG
    Martin Gramatzki

    Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany

    2 publications · 118 citations

    2

    h-index

  2. MH
    Michael Hust

    Technische Universität Braunschweig, Germany

    2 publications · 154 citations

    2

    h-index

  3. MP
    Matthias Peipp

    Christian-Albrechts-Universität zu Kiel, Germany

    2 publications · 118 citations

    2

    h-index

  4. SD
    Stefan Dübel

    Technische Universität Braunschweig, Germany

    2 publications · 154 citations

    2

    h-index

  5. CK
    Christian Kellner

    Christian-Albrechts-Universität zu Kiel, Germany

    2 publications · 118 citations

    2

    h-index

1–5 of 263

Institutions

74

  1. University of California, San Francisco

    San Francisco, United States

    3 h-index

    6 publications

    212 citations

  2. University of Wisconsin–Madison

    Madison, United States

    2 h-index

    3 publications

    63 citations

  3. Christian-Albrechts-Universität zu Kiel

    Kiel, Germany

    2 h-index

    21 publications

    1.1K citations

  4. Hospital for Sick Children

    Toronto, Canada

    2 h-index

    6 publications

    110 citations

  5. Technische Universität Braunschweig

    Braunschweig, Germany

    2 h-index

    11 publications

    1.3K citations

  6. Stanford University

    Stanford, United States

    2 h-index

    10 publications

    455 citations

  7. Boehringer Ingelheim (Germany)

    Ingelheim, Germany

    2 h-index

    5 publications

    195 citations

  8. Ludwig-Maximilians-Universität München

    Munich, Germany

    2 h-index

    5 publications

    143 citations

1–8 of 74

Venues

  1. Journal of Biological Chemistry

    JBC · 2 publications · 127 citations

    2

    h-index

  2. Frontiers in Immunology

    3 publications · 135 citations

    2

    h-index

  3. Clinical Toxicology

    1 publications · 13 citations

    1

    h-index

  4. European Cells and Materials

    1 publications · 17 citations

    1

    h-index

  5. PubMed

    Repository · 1 publications · 98 citations

    1

    h-index

1–5