Concepedia

Fork Degradation

Fork Degradation is the pathological dismantling of stalled DNA replication forks by nucleases, distinguished from other replication stress responses by its irreversible erosion of nascent DNA strands that compromises genomic integrity.

86

Publications

9.4K

Citations

527

Authors

207

Institutions

Publications per year

2017–2026

48

Variants

Replication Fork Degradation

Parents

Publications

86

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

Katharina Schlacher, Nicole Christ, Nicolas Siaud et al. · Cell · 2011 · 1.3K citations · Full text

, , +14

Geminin, an Inhibitor of DNA Replication, Is Degraded during Mitosis

Thomas J. McGarry, Marc W. Kirschner · Cell · 1998 · 896 citations · Full text

, , +14

Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage

Luca Busino, Maddalena Donzelli, Massimo Chiesa et al. · Nature · 2003 · 440 citations

, , +14

MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells

Delphine Lemaçon, Jessica Jackson, Annabel Quinet et al. · Nature Communications · 2017 · 417 citations · Full text

, , +16

Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments

Arun Mouli Kolinjivadi, Vincenzo Sannino, Anna De Antoni et al. · Molecular Cell · 2017 · 377 citations · Full text

, , +17

1–5 of 86

Authors

527

  1. JJ
    Jessica Jackson

    Saint Louis University, United States

    5 publications · 886 citations

    5

    h-index

  2. JC
    Justin Courcelle

    Portland State University, United States

    5 publications · 345 citations

    5

    h-index

  3. GM
    George‐Lucian Moldovan

    Pennsylvania State University, United States

    4 publications · 269 citations

    4

    h-index

  4. AF
    Annapaola Franchitto

    Istituto Superiore di Sanità, Italy

    4 publications · 272 citations

    4

    h-index

  5. CM
    Claudia M. Nicolae

    Pennsylvania State University, United States

    4 publications · 269 citations

    4

    h-index

1–5 of 527

Institutions

207

  1. Centre National de la Recherche Scientifique

    Paris, France

    8 h-index

    38 publications

    1.6K citations

  2. University of Minnesota

    Minneapolis, United States

    7 h-index

    16 publications

    1.6K citations

  3. Washington University in St. Louis

    St Louis, United States

    6 h-index

    22 publications

    5.2K citations

  4. University of Zurich

    Zurich, Switzerland

    6 h-index

    31 publications

    6K citations

  5. Center for Cancer Research

    Bethesda, United States

    6 h-index

    24 publications

    1.2K citations

  6. Harvard University

    Cambridge, United States

    6 h-index

    28 publications

    5.9K citations

  7. Massachusetts General Hospital

    Boston, United States

    5 h-index

    21 publications

    2.2K citations

  8. Cancer Genetics (United States)

    Rutherford, United States

    5 h-index

    18 publications

    1K citations

1–8 of 207

Venues

  1. Nature Communications

    11 publications · 1.5K citations

    11

    h-index

  2. Molecular Cell

    7 publications · 1.1K citations

    7

    h-index

  3. Nucleic Acids Research

    5 publications · 173 citations

    5

    h-index

  4. Cell Reports

    5 publications · 352 citations

    5

    h-index

  5. Nature Cell Biology

    NCB · 4 publications · 857 citations

    4

    h-index

1–5