Concepedia

Feedback Loop Disruption

Feedback Loop Disruption is a regulatory dysfunction within cellular signaling pathways in which abnormal activation of proto-oncogenes impairs the normal inhibitory mechanisms that maintain homeostatic control, leading to sustained proliferative signaling and loss of negative feedback attenuation.

70

Publications

4.3K

Citations

479

Authors

200

Institutions

Publications per year

2017–2026

29

Parents

Publications

70

MDM2 Suppresses p73 Function without Promoting p73 Degradation

Xiaoya Zeng, Lihong Chen, Christine A. Jost et al. · Molecular and Cellular Biology · 1999 · 330 citations

, , +17

MDM2 and prognosis.

Kenan Onel, Carlos Cordon‐Cardo · PubMed · 2004 · 202 citations

, , +13

MDM2 and Prognosis

Kenan Onel, Carlos Cordon‐Cardo · Molecular Cancer Research · 2004 · 183 citations · Full text

, , +12

Dysfunction of the Reciprocal Feedback Loop between GATA3- and ZEB2-Nucleated Repression Programs Contributes to Breast Cancer Metastasis

Wenzhe Si, Wei Huang, Yu Zheng et al. · Cancer Cell · 2015 · 163 citations · Full text

, , +13

A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control

Limin Li, Jian Liao, Jürgen Ruland et al. · Proceedings of the National Academy of Sciences · 2001 · 159 citations · Full text

, , +13

1–5 of 70

Authors

479

  1. KN
    Kumar Nikhil

    Indian Institute of Technology Roorkee, India

    3 publications · 104 citations

    3

    h-index

  2. FA
    Farrukh Alvi

    Florida State University, United States

    3 publications · 236 citations

    3

    h-index

  3. KS
    Kavita Shah

    Purdue University West Lafayette, United States

    3 publications · 104 citations

    3

    h-index

  4. CS
    Chiang Shih

    Florida State University, United States

    3 publications · 236 citations

    3

    h-index

  5. HS
    Hanan S. Haymour

    Purdue University West Lafayette, United States

    2 publications · 39 citations

    2

    h-index

1–5 of 479

Institutions

200

  1. University of California San Diego

    San Diego, United States

    5 h-index

    26 publications

    2.1K citations

  2. Center for Cancer Research

    Bethesda, United States

    4 h-index

    18 publications

    588 citations

  3. Purdue University West Lafayette

    West Lafayette, United States

    3 h-index

    14 publications

    500 citations

  4. Florida State University

    Tallahassee, United States

    3 h-index

    9 publications

    870 citations

  5. Keio University

    Tokyo, Japan

    3 h-index

    4 publications

    259 citations

  6. Howard Hughes Medical Institute

    Chevy Chase, United States

    3 h-index

    8 publications

    557 citations

  7. King's College London

    London, United Kingdom

    2 h-index

    25 publications

    2.5K citations

  8. National University Cancer Institute, Singapore

    Singapore, Singapore

    2 h-index

    17 publications

    842 citations

1–8 of 200

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 6 publications · 480 citations

    6

    h-index

  2. Cell Reports

    3 publications · 188 citations

    3

    h-index

  3. Journal of Neuroscience

    2 publications · 110 citations

    2

    h-index

  4. Genes & Development

    2 publications · 132 citations

    2

    h-index

  5. European Journal of Endocrinology

    EJE · 2 publications · 45 citations

    2

    h-index

1–5