Concepedia

Fc Receptor Selectivity Engineering

Fc Receptor Selectivity Engineering is a methodological framework within Fc engineering that specifically modulates the binding affinity and specificity of the Fc region of antibodies toward selective Fc receptors to optimize immunological effector functions while minimizing off-target interactions.

13

Publications

710

Citations

112

Authors

38

Institutions

Publications per year

2017–2026

5

Parents

Publications

13

Characterization of the IgG-Fc receptor on human platelets

SP Karas, WF Rosse, RJ Kurlander · Blood · 1982 · 155 citations · Full text

, , +13

Reduction of total IgE by targeted coengagement of IgE B-cell receptor and FcγRIIb with Fc-engineered antibody

Seung Y. Chu, Holly M. Horton, Erik Pong et al. · Journal of Allergy and Clinical Immunology · 2012 · 93 citations

, , +17

Polymeric human Fc-fusion proteins with modified effector functions

David Mekhaiel, Daniel M. Czajkowsky, Jan Terje Andersen et al. · Scientific Reports · 2011 · 83 citations · Full text

, , +17

Highly reduced binding to high and low affinity mouse Fc gamma receptors by L234A/L235A and N297A Fc mutations engineered into mouse IgG2a

E. Arduin, Shilpi Arora, P.R. Bamert et al. · Molecular Immunology · 2014 · 81 citations

, , +8

Fc Engineering Approaches to Enhance the Agonism and Effector Functions of an Anti-OX40 Antibody

Di Zhang, Monica V. Goldberg, Mark L. Chiu · Journal of Biological Chemistry · 2016 · 63 citations · Full text

, , +16

1–5 of 13

Authors

112

  1. RK
    RJ Kurlander

    Duke Medical Center, United States

    2 publications · 171 citations

    2

    h-index

  2. WR
    WF Rosse

    Duke Medical Center, United States

    2 publications · 171 citations

    2

    h-index

  3. SK
    SP Karas

    Duke Medical Center, United States

    2 publications · 171 citations

    2

    h-index

  4. AW
    Ann W Morgan

    University of Leeds, United Kingdom

    1 publications · 42 citations

    1

    h-index

  5. SG
    Sergey Gorlatov

    MacroGenics (United States), United States

    1 publications · 42 citations

    1

    h-index

1–5 of 112

Institutions

38

  1. Rutherford Appleton Laboratory

    Didcot, United Kingdom

    1 h-index

    2 publications

    84 citations

  2. Aarhus University

    Aarhus, Denmark

    1 h-index

    4 publications

    144 citations

  3. University of Oxford

    Oxford, United Kingdom

    1 h-index

    2 publications

    84 citations

  4. Springhouse

    Boston, United States

    1 h-index

    1 publications

    63 citations

  5. Centre for Human Genetics

    Oxford, United Kingdom

    1 h-index

    2 publications

    84 citations

  6. Five Prime Therapeutics (United States)

    South San Francisco, United States

    1 h-index

    1 publications

    11 citations

  7. Shanghai Jiao Tong University

    Shanghai, China

    1 h-index

    3 publications

    249 citations

  8. The University of Queensland

    Brisbane, Australia

    1 h-index

    1 publications

    29 citations

1–8 of 38

Venues

  1. Blood

    2 publications · 171 citations

    2

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    1 publications · 11 citations

    1

    h-index

  3. Journal of Controlled Release

    1 publications · 36 citations

    1

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 1 publications · 42 citations

    1

    h-index

  5. Scientific Reports

    1 publications · 83 citations

    1

    h-index

1–5